From Dartmouth College (J.E.S., C.W.) and Dartmouth Geisel School of Medicine (J.L.B., N.M.R.), Hanover, NH.
Neurology. 2021 Apr 6;96(14):e1913-e1920. doi: 10.1212/WNL.0000000000011701. Epub 2021 Feb 25.
To detail the scope, nature, and disclosure of financial conflicts of interest (COI) between the pharmaceutical and medical device industries (Industry) and authors in high-impact clinical neurology journals.
Using the Centers for Medicare and Medicaid Services Open Payments Database (OPD), we retrieved information on payments from Industry to 2,000 authors from randomly selected 2016 articles in 5 journals. We categorized payments by type (research, general, and associated research/institutional), sponsoring entity, and year (from 2013 to 2016). Each author's self-disclosures were compared to OPD-listed Industry relationships to measure discordance. Payments were manually reviewed to identify those from manufacturers of products that were directly tested or discussed in the article. We also quantified the prevalence and value of these nondisclosed, relevant COI.
Two hundred authors from 158 articles had at least 1 OPD payment. Median/mean annual payments per author were $4,229/$19,586 (general); $1,702/$5,966 (research); and $67,512/$362,102 (associated research). Most neurologists received <$1,000/y (74.6%, 93.0%, and 79.5% for general, research, and associated research, respectively), but a sizeable minority (>10% of authors) received more than $10,000 per year, and several received over $1 million. Of 3,013 payments deemed directly relevant to the article, 50.9% were not self-disclosed by the authors, totaling $5,782,197 ($1,665,603 general; $25,532 research; $4,091,062 associated research).
Industry-related financial relationships are prevalent among United States-based physicians publishing in major neurology journals, and incomplete self-disclosure is common. As a profession, academic and other neurologists must work to establish firm rules to ensure and manage disclosure of financial COI.
详细说明制药和医疗器械行业（工业界）与高影响力临床神经病学杂志作者之间的财务利益冲突（COI）的范围、性质和披露情况。
我们使用医疗保险和医疗补助服务中心的公开支付数据库（OPD），从五个杂志中随机选择的 2016 年的 2000 篇文章中检索了工业界向作者支付的信息。我们按类型（研究、一般和相关研究/机构）、赞助实体和年份（2013 年至 2016 年）对支付进行了分类。将每个作者的自我披露与 OPD 列出的工业界关系进行比较，以衡量不匹配的程度。我们对支付进行了手动审查，以确定那些来自文章中直接测试或讨论的产品制造商的支付。我们还量化了这些未披露的、相关的 COI 的普遍性和价值。
来自 158 篇文章的 200 位作者至少有 1 笔 OPD 支付。每位作者的平均/中位数年度支付额为 4229 美元/19586 美元（一般）、1702 美元/5966 美元（研究）和 67512 美元/362102 美元（相关研究）。大多数神经科医生每年收到的款项少于 1000 美元（分别为 74.6%、93.0%和 79.5%），但相当一部分（超过 10%的作者）每年收到的款项超过 10000 美元，少数人收到的款项超过 100 万美元。在被认为与文章直接相关的 3013 笔款项中，有 50.9%的款项没有被作者自行披露，总额为 5782197 美元（1665603 美元为一般款项；25532 美元为研究款项；4091062 美元为相关研究款项）。
在美国主要神经病学杂志上发表文章的医生中，与工业界相关的财务关系普遍存在，且披露不完整的情况也很常见。作为一个专业，学术和其他神经科医生必须努力建立坚定的规则，以确保和管理财务利益冲突的披露。
