Jordan Allison, Nagaraj Arun, Hoyle J Chad, Stino Amro Maher, Arnold W David, Elsheikh Bakri
Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Front Neurol. 2021 Feb 4;12:613599. doi: 10.3389/fneur.2021.613599. eCollection 2021.
Serum Creatinine Kinase (CK) is a non-specific marker of muscle damage. There has been limited investigation of the association between peripheral neuropathy and CK elevation (hyperCKemia). We performed a chart review to investigate the CK level in peripheral neuropathies. Demographics, clinical history, physical exam, electrodiagnostic data, CK level, statin use, etiology of neuropathy, and concomitant neuromuscular disorders were recorded. HyperCKemia was defined using our laboratory cutoff values of >180 U/L (women) and >220 U/L (men). We identified 450 patients with peripheral neuropathy who had CK testing, 92 (20.4%) of whom had hyperCKemia. Sixty-one of those patients (13.5% of the total figure) had a concomitant etiology that could explain the CK elevation. Thirty-one patients (6.9%) had no other identifiable etiology for their hyperCKemia beyond the neuropathy. The average CK level in the latter cohort with hyperCKemia was 376 U/L (women: 312 U/L; men: 444 U/L). The frequency of cramping was greater in patients with elevated vs. normal CK ( < 0.0001). HyperCKemia can occur in patients with peripheral neuropathy and appears to associate with cramping.
血清肌酸激酶（CK）是肌肉损伤的非特异性标志物。关于周围神经病变与CK升高（高CK血症）之间关联的研究有限。我们进行了一项病历回顾，以调查周围神经病变患者的CK水平。记录了人口统计学信息、临床病史、体格检查、电诊断数据、CK水平、他汀类药物使用情况、神经病变的病因以及伴随的神经肌肉疾病。高CK血症的定义采用我们实验室设定的女性>180 U/L、男性>220 U/L的临界值。我们确定了450例接受CK检测的周围神经病变患者，其中92例（20.4%）患有高CK血症。其中61例患者（占总数的13.5%）有可解释CK升高的伴随病因。31例患者（6.9%）除神经病变外，其高CK血症没有其他可识别的病因。后一组高CK血症患者的平均CK水平为376 U/L（女性：312 U/L；男性：444 U/L）。CK升高的患者与CK正常的患者相比，抽筋的发生率更高（<0.0001）。周围神经病变患者可出现高CK血症，且似乎与抽筋有关。
