Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
Division of Endocrinology and Metabolism, Department of Medicine, Sinai Health System, and Lunenfeld Tanenbaum Research Institute, University of Toronto, Toronto, Canada.
Clin Neurophysiol. 2018 Jan;129(1):122-126. doi: 10.1016/j.clinph.2017.10.029. Epub 2017 Nov 11.
To explore the correlations between different muscle cramp characteristics including cramp frequency and severity and clinical and large and small nerve fiber measures in patients with diabetes type 1 (DM 1) and 2 (DM 2).
Prospective cross sectional study of healthy controls and patients with DM 1 and DM 2 recruited between April 2009 and November 2012. Participants underwent clinical evaluation and large and small nerve fiber studies, and the frequency and correlations of muscle cramps were explored.
37 controls, 51 patients with DM 1, and 69 patients with DM 2 were studied. Muscle cramps were the most frequent symptom captured by the Toronto Clinical Neuropathy Score (TCNS) in all groups, up to 78% in patients with DM 2. In patients with DM 1, but not DM 2, muscle cramp frequency and severity were correlated with clinical (TCNS) and both large (electrophysiology and vibration perception thresholds) and small nerve fiber measures.
Muscle cramps are frequent in diabetes and are correlated with clinical and both small and large nerve fiber measures in DM 1, suggesting that their origin and propagation might extend beyond the motor nerve.
Muscle cramps correlate with nerve fiber measures in DM 1.
探讨不同肌肉痉挛特征（包括痉挛频率和严重程度）与 1 型糖尿病（DM1）和 2 型糖尿病（DM2）患者临床及大、小纤维神经测量值之间的相关性。
2009 年 4 月至 2012 年 11 月期间，前瞻性纳入健康对照者和 DM1、DM2 患者进行横断面研究。参与者接受临床评估和大、小纤维神经研究，并探讨肌肉痉挛的频率及其相关性。
共纳入 37 名对照者、51 名 DM1 患者和 69 名 DM2 患者。在所有组中，肌肉痉挛都是多伦多临床神经病变评分（TCNS）最常记录到的症状，在 DM2 患者中高达 78%。在 DM1 患者中，肌肉痉挛的频率和严重程度与临床（TCNS）和大（电生理和振动感觉阈值）、小纤维神经测量值均相关，但在 DM2 患者中无相关性。
肌肉痉挛在糖尿病中很常见，与 DM1 患者的临床和大小纤维神经测量值相关，提示其起源和传播可能超出运动神经。
DM1 中的肌肉痉挛与神经纤维测量值相关。
