Cohen-Kurzrock Rena A, Riahi Ryan R
Health Administration, Louisiana State University of Shreveport, Shreveport, USA.
Dermatology, DermSurgery Associates, Sugar Land, USA.
Cureus. 2021 Jan 22;13(1):e12862. doi: 10.7759/cureus.12862.
The appearance of cutaneous metastases from breast carcinoma is variable and can present as nodules or inflammation of the skin, mimicking benign skin conditions. In addition, the skin lesions may be the initial presentation of unsuspected visceral malignancy or the site of either persistence or recurrence of metastatic disease in an oncology patient with a history of a solid tumor. The features of a woman with metastatic breast cancer that presented as a nodule that was masked by her concurrent, new-onset, hidradenitis suppurativa are reported. The diagnosis was suspected when the skin nodule persisted after her hidradenitis suppurativa improved; the diagnosis of cutaneous metastasis was confirmed with a skin biopsy. Occult breast cancer (primary or recurrent disease) may be masked by an inflammatory condition, such as hidradenitis suppurativa. Therefore, if a primary dermatologic condition does not appropriately respond to therapy, pathologic evaluation may be warranted to exclude the possibility of another disease, such as cutaneous metastases from underlying visceral cancer.
乳腺癌皮肤转移的表现多样，可呈现为结节或皮肤炎症，酷似良性皮肤疾病。此外，皮肤病变可能是未被怀疑的内脏恶性肿瘤的首发表现，或者是有实体瘤病史的肿瘤患者转移性疾病持续存在或复发的部位。本文报告了一名转移性乳腺癌女性患者，其表现为一个结节，被同时新发的化脓性汗腺炎所掩盖。当她的化脓性汗腺炎好转后皮肤结节仍持续存在时，怀疑有转移；皮肤活检证实为皮肤转移。隐匿性乳腺癌（原发性或复发性疾病）可能被炎症性疾病如化脓性汗腺炎所掩盖。因此，如果原发性皮肤病对治疗反应不佳，可能需要进行病理评估以排除其他疾病的可能性，如潜在内脏癌的皮肤转移。
