Long Non-Coding RNA ELFN1-AS1 Promoted Colon Cancer Cell Growth and Migration the miR-191-5p/Special AT-Rich Sequence-Binding Protein 1 Axis.

Long non-coding RNAs (lncRNAs) are reported to participate in tumor development. It has been manifested in previous researches that lncRNA is involved in early-stage colon adenocarcinoma with potential diagnostic value. However, no studies have revealed the specific mechanism of in colon cancer, and there are no other studies on whether is associated with tumorigenesis. In our study, with high expression in colon cancer was selected by TCGA analysis, and the survival analysis was carried out to verify it. Subsequently, qRT-PCR was adopted for validating the results in tissues and cell lines. Cell counting kit-8 (CCK8), 5-ethynyl-2'-deoxyuridine (EdU), cell colon, cell apoptosis, cell cycle, cell migration, and invasion assays were utilized to assess the role of in colon cancer. Results uncovered that expression was prominently raised in colon cancer cells and tissues. decrement restrained cells to grow through interfering with distribution of cell cycle and promoting apoptosis. Meanwhile, decrement weakened the capacity of cells to migrate and invade. What's more, was uncovered to act as a competing endogenous RNA (ceRNA) to decrease miR-191-5p expression, thus raising (), a downstream target of ceRNA. To sum up, drives colon cancer cells to proliferate and invade through adjusting the miR-191-5p/ axis. The above results disclose that lncRNA is possibly a novel treatment target for colon cancer cases.