《遗传性肿瘤进化作用的理论》

, A Theory of the Evolutionary Role of Hereditary Tumors.

机构信息

Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina Street, 117971 Moscow, Russia.

Peter the Great St. Petersburg Polytechnic University, 29 Polytekhnicheskaya Street, 195251 St. Petersburg, Russia.

出版信息

Int J Mol Sci. 2023 May 11;24(10):8611. doi: 10.3390/ijms24108611.

DOI:10.3390/ijms24108611

PMID:37239953

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10217919/

Abstract

A theory of the evolutionary role of hereditary tumors, or the theory, is being developed. The main hypothesis of the theory, the hypothesis of evolution by tumor neofunctionalization, posits that hereditary tumors provided additional cell masses during the evolution of multicellular organisms for the expression of evolutionarily novel genes. The theory has formulated several nontrivial predictions that have been confirmed in the laboratory of the author. It also suggests several nontrivial explanations of biological phenomena previously unexplained by the existing theories or incompletely understood. By considering three major types of biological development-individual, evolutionary, and neoplastic development-within one theoretical framework, the theory has the potential to become a unifying biological theory.

摘要

一个关于遗传性肿瘤进化作用的理论，即所谓的“肿瘤进化新功能化理论”正在被发展。该理论的主要假说，即肿瘤进化新功能化假说，认为遗传性肿瘤在多细胞生物进化过程中提供了额外的细胞群体，以表达进化中新的基因。该理论已经提出了几个重要的预测，这些预测已在作者的实验室中得到证实。它还对一些以前没有被现有理论完全解释或理解的生物学现象提出了一些重要的解释。通过在一个理论框架内考虑三种主要类型的生物发育——个体发育、进化发育和肿瘤发育，该理论有可能成为一个统一的生物学理论。