SNFIMCMDA:用于miRNA-疾病关联预测的相似性网络融合与归纳矩阵补全

SNFIMCMDA: Similarity Network Fusion and Inductive Matrix Completion for miRNA-Disease Association Prediction.

作者信息

Li Lei, Gao Zhen, Zheng Chun-Hou, Wang Yu, Wang Yu-Tian, Ni Jian-Cheng

机构信息

School of Software, Qufu Normal University, Qufu, China.

School of Computer Science and Technology, Anhui University, Hefei, China.

出版信息

Front Cell Dev Biol. 2021 Feb 9;9:617569. doi: 10.3389/fcell.2021.617569. eCollection 2021.

Abstract

MicroRNAs (miRNAs) that belong to non-coding RNAs are verified to be closely associated with several complicated biological processes and human diseases. In this study, we proposed a novel model that was Similarity Network Fusion and Inductive Matrix Completion for miRNA-Disease Association Prediction (SNFIMCMDA). We applied inductive matrix completion (IMC) method to acquire possible associations between miRNAs and diseases, which also could obtain corresponding correlation scores. IMC was performed based on the verified connections of miRNA-disease, miRNA similarity, and disease similarity. In addition, miRNA similarity and disease similarity were calculated by similarity network fusion, which could masterly integrate multiple data types to obtain target data. We integrated miRNA functional similarity and Gaussian interaction profile kernel similarity by similarity network fusion to obtain miRNA similarity. Similarly, disease similarity was integrated in this way. To indicate the utility and effectiveness of SNFIMCMDA, we both applied global leave-one-out cross-validation and five-fold cross-validation to validate our model. Furthermore, case studies on three significant human diseases were also implemented to prove the effectiveness of SNFIMCMDA. The results demonstrated that SNFIMCMDA was effective for prediction of possible associations of miRNA-disease.

摘要

属于非编码RNA的微小RNA(miRNA)已被证实与多种复杂的生物学过程和人类疾病密切相关。在本研究中,我们提出了一种新的模型,即用于miRNA-疾病关联预测的相似性网络融合与归纳矩阵补全模型(SNFIMCMDA)。我们应用归纳矩阵补全(IMC)方法来获取miRNA与疾病之间可能的关联,同时还能获得相应的相关分数。IMC是基于已验证的miRNA-疾病连接、miRNA相似性和疾病相似性来执行的。此外,通过相似性网络融合计算miRNA相似性和疾病相似性,它可以巧妙地整合多种数据类型以获得目标数据。我们通过相似性网络融合整合miRNA功能相似性和高斯相互作用谱核相似性以获得miRNA相似性。同样,疾病相似性也以这种方式进行整合。为了表明SNFIMCMDA的实用性和有效性,我们应用了全局留一法交叉验证和五折交叉验证来验证我们的模型。此外,还对三种重大人类疾病进行了案例研究,以证明SNFIMCMDA的有效性。结果表明,SNFIMCMDA对于预测miRNA-疾病的可能关联是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f95d/7900415/dd3bb9f9157d/fcell-09-617569-g001.jpg

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