Department of Veterinary Clinical Medicine, University of Illinois, Urbana-Champaign, Illinois, USA.
J Vet Intern Med. 2021 Mar;35(2):812-822. doi: 10.1111/jvim.16067. Epub 2021 Feb 26.
Cardiac magnetic resonance imaging (CMR) allows for detection of fibrosis in hypertrophic cardiomyopathy (HCM) by quantification of the extracellular volume fraction (ECV).
HYPOTHESIS/OBJECTIVES: To quantify native T1 mapping and ECV in cats. We hypothesize that native T1 mapping and ECV will be significantly increased in HCM cats compared with healthy cats.
Seventeen healthy and 12 preclinical HCM, age-matched, client-owned cats.
Prospective observational study. Tests performed included indirect blood pressure, CBC, biochemical analysis including total thyroid, urinalysis, transthoracic echocardiogram, and CMR. Cats were considered healthy if all tests were within normal limits and a diagnosis of HCM was determined by the presence of left ventricular concentric hypertrophy ≥6 mm on echocardiography.
There were statistically significant differences in LV mass (healthy = 5.87 g, HCM = 10.3 g, P < .0001), native T1 mapping (healthy = 1122 ms, HCM = 1209 ms, P = .004), and ECV (healthy = 26.0%, HCM = 32.6%, P < .0001). Variables of diastolic function including deceleration time of early diastolic transmitral flow (DTE), ratio between peak velocity of early diastolic transmitral flow and peak velocity of late diastolic transmitral flow (E : A), and peak velocity of late diastolic transmitral flow (A wave) were significantly correlated with ECV (DTE; r = 0.73 P = .007, E : A; r = -0.75 P = .004, A wave; r = 0.76 P = .004).
Quantitative assessment of cardiac ECV is feasible and can provide additional information not available using echocardiography.
心脏磁共振成像（CMR）通过量化细胞外容积分数（ECV）可检测肥厚型心肌病（HCM）中的纤维化。
假设/目的：量化猫的心脏固有 T1 映射和 ECV。我们假设与健康猫相比，HCM 猫的心脏固有 T1 映射和 ECV 会显著增加。
17 只健康和 12 只临床前 HCM、年龄匹配的、有主人的猫。
前瞻性观察研究。进行的测试包括间接血压、全血细胞计数、包括总甲状腺在内的生化分析、尿液分析、经胸超声心动图和 CMR。如果所有测试均在正常范围内且超声心动图显示左心室向心性肥厚≥6mm 可诊断为 HCM，则认为猫健康。
LV 质量（健康=5.87g，HCM=10.3g，P<.0001）、固有 T1 映射（健康=1122ms，HCM=1209ms，P=0.004）和 ECV（健康=26.0%，HCM=32.6%，P<.0001）存在统计学差异。舒张功能变量，包括舒张早期二尖瓣血流减速时间（DTE）、舒张早期二尖瓣血流峰值速度与舒张晚期二尖瓣血流峰值速度的比值（E:A）和舒张晚期二尖瓣血流峰值速度（A 波）与 ECV 呈显著相关（DTE；r=0.73，P=0.007，E:A；r=-0.75，P=0.004，A 波；r=0.76，P=0.004）。
心脏 ECV 的定量评估是可行的，可以提供超声心动图无法提供的额外信息。
