Gross Gerd E, Werner Ricardo N, Avila Valle Gabriela L, Bickel Markus, Brockmeyer Norbert H, Doubek Klaus, Gallwas Julia, Gieseking Friederike, Haase Heidemarie, Hillemanns Peter, Ikenberg Hans, Jongen Johannes, Kaufmann Andreas M, Klußmann Jens Peter, von Knebel Doeberitz Magnus, Knuf Markus, Köllges Ralf, Laws Hans-Jürgen, Mikolajczyk Rafael, Neis Klaus J, Petry Karl-Ulrich, Pfister Herbert, Schlaeger Martin, Schneede Peter, Schneider Achim, Smola Sigrun, Tiews Sven, Nast Alexander, Gaskins Matthew, Wieland Ulrike
Department of Dermatology and Venereology, University Hospital Rostock, Rostock, Germany.
Paul Ehrlich Society for Chemotherapy, HPV Management Forum, Germany.
J Dtsch Dermatol Ges. 2021 Mar;19(3):479-494. doi: 10.1111/ddg.14438. Epub 2021 Feb 26.
Anogenital and oropharyngeal infections with human papilloma viruses (HPV) are common. Clinically manifest disease may significantly impact quality of life; the treatment of HPV-associated lesions is associated with a high rate of recurrence and invasive neoplasms, such as cervical, anal, vulvar, penile, and oropharyngeal cancers, which are characterized by significant morbidity and mortality. Vaccination against HPV is an effective and safe measure for the primary prevention of HPV-associated lesions, but immunization rates are still low in Germany. The present publication is an abridged version of the German evidence and consensus-based guideline "Vaccination recommendations for the prevention of HPV-associated lesions", which is available on the website of the German Association of the Scientific Medical Societies (AWMF). On the basis of a systematic review with meta-analyses, a representative panel developed and agreed upon recommendations for the vaccination of different populations against HPV. In addition, consensus-based recommendations were developed for specific issues relevant to everyday practice. Based on current evidence and a representative expert consensus, these recommendations are intended to provide guidance in a field in which there is often uncertainty and in which both patients and health care providers are sometimes confronted with controversial and emotionally charged points of view.
人乳头瘤病毒（HPV）引起的肛门生殖器和口咽感染很常见。临床表现出的疾病可能会对生活质量产生重大影响；HPV相关病变的治疗与高复发率以及侵袭性肿瘤有关，如宫颈癌、肛门癌、外阴癌、阴茎癌和口咽癌，这些肿瘤具有很高的发病率和死亡率。HPV疫苗接种是预防HPV相关病变的有效且安全的措施，但在德国，免疫接种率仍然很低。本出版物是德国基于证据和共识的指南《预防HPV相关病变的疫苗接种建议》的精简版，该指南可在德国科学医学协会（AWMF）的网站上获取。在进行荟萃分析的系统评价基础上，一个代表性小组制定并商定了针对不同人群接种HPV疫苗的建议。此外，还针对日常实践中的特定问题制定了基于共识的建议。基于当前证据和具有代表性的专家共识，这些建议旨在为一个常常存在不确定性、患者和医疗服务提供者有时会面临有争议且情绪化观点的领域提供指导。
