Al-Janabi Ali Abdul Hussein S
Karbala University College of Medicine, Department of Microbiology, Karbala, Iraq.
Turk J Pharm Sci. 2021 Feb 25;18(1):68-74. doi: 10.4274/tjps.galenos.2019.23500.
Tamoxifen (TAM), which is used for treating breast cancer, has exhibited another important function as an antimicrobial agent. The objective of this study is to investigate the antibacterial action of TAM against the bacteria present in the human oral cavity.
The bacteria present in the human oral cavity were isolated from healthy individuals. Different concentrations of TAM were tested against the isolated bacteria. Additionally, bactericidal and bacteriostatic effects of TAM were also determined.
Out of 23 isolated bacteria, a greater number of Gram-positive bacteria were highly susceptible to the low concentrations of TAM than Gram-negative bacteria. , which is Gram-positive bacterium, and , which is Gram-negative bacterium, needed a high minimum inhibitory concentration value of TAM (2.5 mg/mL) to be inhibited by TAM's bacteriostatic action. Resistance to TAM was also observed in three strains of Gram-positive and four strains of Gram-negative bacteria.
TAM has shown a potential antibacterial effect against the bacteria present in the oral cavity, especially against Gram-positive bacteria. This effect is mostly bacteriostatic. This study also found bacterial resistance toward TAM.
用于治疗乳腺癌的他莫昔芬（TAM）已展现出作为抗菌剂的另一重要功能。本研究的目的是调查TAM对存在于人体口腔中的细菌的抗菌作用。
从健康个体中分离出存在于人体口腔中的细菌。针对分离出的细菌测试不同浓度的TAM。此外，还确定了TAM的杀菌和抑菌作用。
在23株分离出的细菌中，相较于革兰氏阴性菌，更多的革兰氏阳性菌对低浓度的TAM高度敏感。革兰氏阳性菌金黄色葡萄球菌和革兰氏阴性菌牙龈卟啉单胞菌需要较高的TAM最小抑菌浓度值（2.5毫克/毫升）才能被TAM的抑菌作用抑制。在三株革兰氏阳性菌和四株革兰氏阴性菌中也观察到了对TAM的耐药性。
TAM已显示出对口腔中存在的细菌具有潜在的抗菌作用，尤其是对革兰氏阳性菌。这种作用主要是抑菌作用。本研究还发现了细菌对TAM的耐药性。
