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通过靶向内源性白细胞介素-30 来抑制三阴性乳腺癌的进展需要 IFNγ 信号。

Hindering triple negative breast cancer progression by targeting endogenous interleukin-30 requires IFNγ signaling.

机构信息

Department of Medicine and Sciences of Aging, "G. d'Annunzio" University, Chieti, Italy.

Anatomic Pathology and Immuno-Oncology Unit, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.

出版信息

Clin Transl Med. 2021 Feb;11(2):e278. doi: 10.1002/ctm2.278.

DOI:10.1002/ctm2.278
PMID:33635005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7828256/
Abstract

IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells.

摘要

IL30mRNA 的表达与三阴性乳腺癌（TNBC）亚型相关。IL30 可促进 TNBC 细胞的增殖和迁移，并重塑其免疫基因表达谱。内源性 IL30 的缺乏会阻碍 TNBC 的生长和进展，并延长宿主的存活时间。由于缺乏内源性 IL30，TNBC 的生长抑制需要 T 和 NK 细胞产生 INFγ。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/92f858e2a0e0/CTM2-11-e278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/10a651483f0a/CTM2-11-e278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/6c510fd8e8b2/CTM2-11-e278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/92f858e2a0e0/CTM2-11-e278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/10a651483f0a/CTM2-11-e278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/6c510fd8e8b2/CTM2-11-e278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4056/7828256/92f858e2a0e0/CTM2-11-e278-g003.jpg

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