Tomalski M D, Bruce W A, Travis J, Blum M S
Department of Entomology, University of Georgia, Athens 30602.
Toxicon. 1988;26(2):127-32. doi: 10.1016/0041-0101(88)90164-x.
Homogenates of whole mites (Pyemotes tritici) paralyze larvae of the greater wax moth Galleria mellonella. Injection of these homogenates into larvae produces symptoms identical to those obtained by bites from female mites. Since the paralytic activity is destroyed by heat and proteolytic enzymes and retained during dialysis, the toxic compounds appear to be proteins. Two protein fractions which differ both in molecular weight and toxicity were found following gel filtration of whole mite extracts. Larvae that are injected with proteins from the high molecular weight (c. 250,000) fraction (designated TxP-HMW) develop flaccid-muscle paralysis after 4-12 hr, while proteins in the low molecular weight fraction (c. 21,000) (designated TxP-LMW) induce a rapid, muscle-contracting paralysis.
全螨（麦氏蒲螨）匀浆可使大蜡螟幼虫麻痹。将这些匀浆注射到幼虫体内会产生与雌螨叮咬后相同的症状。由于麻痹活性会被加热和蛋白水解酶破坏，并在透析过程中得以保留，因此有毒化合物似乎是蛋白质。对全螨提取物进行凝胶过滤后，发现了两种分子量和毒性均不同的蛋白质组分。注射高分子量（约250,000）组分（命名为TxP - HMW）中的蛋白质的幼虫，在4 - 12小时后会出现肌肉松弛性麻痹，而低分子量组分（约21,000）（命名为TxP - LMW）中的蛋白质会引发快速的肌肉收缩性麻痹。
