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来自曲纹暗蛛(Hololena curta)的麻痹性和杀虫性毒素。

Paralytic and insecticidal toxins from the funnel web spider, Hololena curta.

作者信息

Quistad G B, Reuter C C, Skinner W S, Dennis P A, Suwanrumpha S, Fu E W

机构信息

Sandoz Crop Protection Corporation, Palo Alto, CA 94304-1104.

出版信息

Toxicon. 1991;29(3):329-36. doi: 10.1016/0041-0101(91)90286-z.

DOI:10.1016/0041-0101(91)90286-z
PMID:2048147
Abstract

One peptide and ten acylpolyamine toxins (curtatoxins) were purified and identified from venom of Hololena curta. The acylpolyamines consist of six different polyamines which are amidated with three different aromatic acids: (3-indolyl)acetic, (4-hydroxy-3-indolyl)acetic and 2.5-dihydroxybenzoic acids. These acylpolyamines instantly paralyze lepidopteran larvae following injection. The most potent insecticidal peptide in H. curta venom contains 38 amino acids and is lethal at 4 micrograms/g when injected into Manduca sexta larvae.

摘要

从短孔蛛(Hololena curta)的毒液中纯化并鉴定出一种肽和十种酰基多胺毒素(短孔蛛毒素)。这些酰基多胺由六种不同的多胺组成,它们与三种不同的芳香酸酰胺化:(3-吲哚基)乙酸、(4-羟基-3-吲哚基)乙酸和2,5-二羟基苯甲酸。这些酰基多胺注射后能立即使鳞翅目幼虫麻痹。短孔蛛毒液中最有效的杀虫肽含有38个氨基酸,注射到烟草天蛾幼虫体内时,致死剂量为4微克/克。

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