de Courten-Myers G, Myers R E, Schoolfield L
University of Cincinnati College of Medicine, Department of Pathology and Laboratory Medicine, Ohio 45267-0533.
Stroke. 1988 May;19(5):623-30. doi: 10.1161/01.str.19.5.623.
We investigated the influence of serum glucose concentration on infarct size following middle cerebral artery occlusion in cats. These animals were deprived of food for 48 hours and infused with 1) saline for 1 hour before and 8 hours after occlusion (n = 8), 2) 10% glucose solution for 1 hour before and 6 hours after occlusion and saline for 2 additional hours (n = 8), or 3) 10% glucose for 1 hour before and saline for 8 hours after occlusion (n = 5). Nineteen cats killed after 2 weeks' survival were subjected to morphometric infarct size determinations. Eight normoglycemic and 11 hyperglycemic cats exhibited infarcts affecting 10.2 +/- 3.4% and 29.5 +/- 6.5% (mean +/- SEM) of their middle cerebral artery territories, respectively (p less than 0.02). Cats of the two hyperglycemic groups showed similarly sized infarcts. However, two of eight (25%) of cats with preocclusion and postocclusion hyperglycemia died 8 and 24 hours after occlusion with infarction of the entire middle cerebral artery territory, marked hemispheral edema, and brainstem compression. Our results demonstrate that serum glucose concentration at the time of large cerebral vessel occlusion influences stroke outcome.
我们研究了血清葡萄糖浓度对猫大脑中动脉闭塞后梗死灶大小的影响。这些动物禁食48小时，并在闭塞前1小时和闭塞后8小时输注1）生理盐水（n = 8），2）10%葡萄糖溶液在闭塞前1小时和闭塞后6小时输注，随后再输注2小时生理盐水（n = 8），或3）10%葡萄糖在闭塞前1小时输注，闭塞后8小时输注生理盐水（n = 5）。对存活2周后处死的19只猫进行梗死灶大小的形态学测定。8只血糖正常的猫和11只血糖升高的猫梗死灶分别累及大脑中动脉供血区的10.2±3.4%和29.5±6.5%（平均值±标准误）（p<0.02）。两个血糖升高组的猫梗死灶大小相似。然而，在闭塞前和闭塞后血糖升高的8只猫中有2只（25%）在闭塞后8小时和24小时死亡，整个大脑中动脉供血区梗死，伴有明显的半球水肿和脑干受压。我们的结果表明，大脑大血管闭塞时的血清葡萄糖浓度影响卒中结局。
