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医务人员专业类型与新开含可待因、氢可酮、羟考酮和曲马多处方的几率:在 CDC 阿片类药物处方指南发布前后。

Provider specialty and odds of a new codeine, hydrocodone, oxycodone and tramadol prescription before and after the CDC opioid prescribing guideline publication.

机构信息

Department of Family and Community Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, United States of America.

Department of Family and Community Medicine, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, United States of America; AHEAD Institute, Saint Louis University School of Medicine, Salus Center, 4th Floor, 3545, Lafayette Ave., St. Louis, MO 63104, United States of America.

出版信息

Prev Med. 2021 May;146:106466. doi: 10.1016/j.ypmed.2021.106466. Epub 2021 Feb 23.

Abstract

The CDC Guideline for Prescribing Opioids for Chronic Pain cautioned against high dose prescribing but did not provide guidance on type of opioid for new pain episodes. We determined if new prescriptions for Schedule II opioids vs. tramadol decreased in the 18 months after vs. before the CDC guideline and if this decrease was associated with physician specialty. New opioid prescriptions, provider type and covariates were measured using a nationally distributed, Optum® de-identified Electronic Health Record (EHR) data base. Eligible patients were free of cancer and HIV and started a new prescription for Schedule II opioids (i.e. codeine, hydrocodone, oxycodone) or Schedule IV (tramadol) in the 18 months before (n = 141,219) or 18 months after (n = 138,216) guideline publication. Fully adjusted multilevel multinomial models estimated the association between provider type (anesthesiology/pain medicine, surgical specialty, emergency, hospital, primary care, other specialty and unknown) before and after adjusting for covariates. New oxycodone prescriptions were most common among surgical and anesthesia/pain management, and new tramadol prescriptions were most common in primary care. The greatest decreases in odds of a Schedule II opioid vs. tramadol were observed in emergency care (oxycodone vs. tramadol OR = 0.82; 95%CI:0.76-0.88) and primary care (hydrocodone vs. tramadol OR = 0.85; 95%CI:0.81-0.89). Surgical specialists were least likely to start opioid therapy with tramadol. In the 18 months after vs. before the CDC guideline, emergency care and primary care providers increased tramadol prescribing. Guidelines tailored to specialists that frequently begin opioid therapy with oxycodone may enhance safe opioid prescribing.

摘要

美国疾病预防控制中心(CDC)发布的《慢性疼痛阿片类药物处方指南》警告避免高剂量处方,但未就新发疼痛病例中阿片类药物的类型提供指导。我们确定在 CDC 指南发布前后的 18 个月内,新开出的 II 类阿片类药物(即可待因、氢可酮、羟考酮)与曲马多的处方数量是否减少,以及这种减少是否与医生专业有关。新的阿片类药物处方、提供者类型和协变量使用全美分发的 Optum®去识别电子健康记录(EHR)数据库进行测量。符合条件的患者无癌症和 HIV,在 18 个月前(n=141219)或 18 个月后(n=138216)指南发布前开始服用新的 II 类阿片类药物(即可待因、氢可酮、羟考酮)或 IV 类(曲马多)处方。完全调整后的多层次多项逻辑回归模型估计了提供者类型(麻醉/疼痛管理、外科专业、急诊、医院、初级保健、其他专业和未知)在调整协变量前后与新处方之间的关联。新的羟考酮处方最常见于外科和麻醉/疼痛管理,而新的曲马多处方最常见于初级保健。在急诊(羟考酮与曲马多 OR=0.82;95%CI:0.76-0.88)和初级保健(氢可酮与曲马多 OR=0.85;95%CI:0.81-0.89)中,与曲马多相比,II 类阿片类药物的可能性降低幅度最大。外科专家最不可能开始曲马多治疗阿片类药物。与 CDC 指南发布前相比,在发布后 18 个月内,急诊和初级保健提供者增加了曲马多的处方。针对经常开始用羟考酮治疗阿片类药物的专家量身定制的指南可能会增强安全的阿片类药物处方。

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