抗风湿药物对外周血单个核细胞体外促有丝分裂刺激的影响。
Effects of anti-rheumatic drugs on in vitro mitogenic stimulation of peripheral blood mononuclear cells.
作者信息
Dijkmans B A, de Vries E, de Vreede T M, Cats A
机构信息
Department of Rheumatology, Leiden University Hospital, The Netherlands.
出版信息
Transplant Proc. 1988 Apr;20(2 Suppl 2):253-8.
The efficacy of bromocriptine, chloroquine, and Cs was quantitated in an in vitro system, with the use of mitogen-stimulated human PBMC. A concentration-dependent effect was found for each drug. Based on counts of blast cells, Cs was roughly 70 times more effective than either bromocriptine or chloroquine. Besides quantitative comparison of the effect of the drugs, the in vitro system permits conclusions concerning drug combinations. The effect of the combination of bromocriptine and Cs was equal to the expected effects of the separate drugs. However, the combined effect of chloroquine and Cs exceeded the sum of the effects of the individual drugs, which indicates synergy, not addition.
在体外系统中，使用丝裂原刺激的人外周血单个核细胞（PBMC）对溴隐亭、氯喹和环孢素（Cs）的疗效进行了定量分析。发现每种药物都有浓度依赖性效应。基于母细胞计数，环孢素的效力大约是溴隐亭或氯喹的70倍。除了对药物效果进行定量比较外，该体外系统还能得出有关药物组合的结论。溴隐亭和环孢素联合使用的效果等同于单独使用这两种药物的预期效果。然而，氯喹和环孢素联合使用的效果超过了这两种药物单独使用效果的总和，这表明存在协同作用，而非相加作用。
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