2053 名柏林老龄化研究 II 参与者的 BDNF 血清浓度。
BDNF serum concentrations in 2053 participants of the Berlin Aging Study II.
机构信息
College of Life Sciences, University of Leicester, Leicester, UK; Leicestershire Partnership National Health Service Trust, Leicester, UK.
Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin (CSB), Berlin, Germany.
出版信息
Neurobiol Aging. 2021 May;101:221-223. doi: 10.1016/j.neurobiolaging.2021.01.020. Epub 2021 Feb 2.
Serum BDNF concentrations in 2053 participants of the Berlin Aging Study II (BASE-II; 1572 individuals from the older age group [60-85 years], 481 individuals from the younger-age reference group [22-37 years]) were studied. There was no effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations. Multiple linear regression analysis failed to detect significant relationships of Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score to BDNF levels. However, we detected a positive correlation between platelet counts and BDNF levels (r = 0.303, p < 0.001). Our findings do not support an effect of aging, self-reported depression, or the Val66Met variant on serum BDNF concentrations. The role of thrombocytes in the biology of serum BDNF merits further study.
研究了 2053 名柏林老龄化研究 II （BASE-II）参与者的血清 BDNF 浓度（老年组[60-85 岁]的 1572 名个体，年轻参考组[22-37 岁]的 481 名个体）。年龄、性别、体重指数、自我报告的抑郁或 BDNF Val66Met 变体对血清 BDNF 浓度没有影响。多元线性回归分析未能检测到数字符号替换测试评分和阿尔茨海默病登记册建立联盟记忆评分与 BDNF 水平之间的显著关系。然而，我们检测到血小板计数与 BDNF 水平之间存在正相关（r=0.303，p<0.001）。我们的研究结果不支持衰老、自我报告的抑郁或 Val66Met 变体对血清 BDNF 浓度的影响。血小板在血清 BDNF 生物学中的作用值得进一步研究。
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