Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
J Alzheimers Dis. 2021;80(3):1139-1149. doi: 10.3233/JAD-200371.
Brain-derived neurotropic factor (BDNF) plays a vital role in neuronal survival and plasticity and facilitates long-term potentiation, essential for memory. Alterations in BDNF signaling have been associated with cognitive impairment, dementia, and Alzheimer's disease. Although peripheral BDNF levels are reduced in dementia patients, it is unclear whether changes in BDNF levels precede or follow dementia onset.
In the present study, we examined the association between BDNF plasma levels and dementia risk over a follow-up period of up to 16 years.
Plasma BDNF levels were assessed in 758 participants of the Rotterdam Study. Dementia was assessed from baseline (1997-1999) to follow-up until January 2016. Associations of plasma BDNF and incident dementia were assessed with Cox proportional hazards models, adjusted for age and sex. Associations between plasma BDNF and lifestyle and metabolic factors are investigated using linear regression.
During a follow up of 3,286 person-years, 131 participants developed dementia, of whom 104 had Alzheimer's disease. We did not find an association between plasma BDNF and risk of dementia (adjusted hazard ratio 0.99; 95%CI 0.84-1.16). BDNF levels were positively associated with age (B = 0.003, SD = 0.001, p = 0.002), smoking (B = 0.08, SE = 0.01, p = < 0.001), and female sex (B = 0.03, SE = 0.01, p = 0.03), but not with physical activity level (B = -0.01, SE = 0.01, p = 0.06).
The findings suggest that peripheral BDNF levels are not associated with an increased risk of dementia.
脑源性神经营养因子（BDNF）在神经元存活和可塑性中发挥着至关重要的作用，并促进长时程增强，这对于记忆至关重要。BDNF 信号的改变与认知障碍、痴呆和阿尔茨海默病有关。尽管痴呆症患者的外周 BDNF 水平降低，但尚不清楚 BDNF 水平的变化是在痴呆症发病之前还是之后发生。
本研究旨在在长达 16 年的随访期间，研究 BDNF 血浆水平与痴呆症风险之间的关系。
在鹿特丹研究的 758 名参与者中评估了 BDNF 血浆水平。痴呆症从基线（1997-1999 年）评估至 2016 年 1 月的随访。使用 Cox 比例风险模型评估 BDNF 血浆水平与痴呆症发病的关系，调整了年龄和性别。使用线性回归研究 BDNF 血浆水平与生活方式和代谢因素之间的关系。
在 3286 人年的随访期间，131 名参与者发展为痴呆症，其中 104 名患有阿尔茨海默病。我们没有发现 BDNF 血浆水平与痴呆症风险之间存在关联（调整后的危险比为 0.99；95%CI 0.84-1.16）。BDNF 水平与年龄呈正相关（B=0.003，SD=0.001，p=0.002）、与吸烟呈正相关（B=0.08，SE=0.01，p<0.001）、与女性性别呈正相关（B=0.03，SE=0.01，p=0.03），但与体力活动水平无关（B=-0.01，SE=0.01，p=0.06）。
这些发现表明，外周 BDNF 水平与痴呆症风险的增加无关。
