大脑性瘫痪成人的工作记忆所依赖的皮质振荡发生改变。
Cortical oscillations that underlie working memory are altered in adults with cerebral palsy.
机构信息
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.
出版信息
Clin Neurophysiol. 2021 Apr;132(4):938-945. doi: 10.1016/j.clinph.2020.12.029. Epub 2021 Feb 11.
OBJECTIVE
This investigation used magnetoencephalography (MEG) to identify the neurophysiological mechanisms contributing to the altered cognition seen in adults with cerebral palsy (CP).
METHODS
Adults with CP (GMFCS levels I-IV) and demographically-matched controls completed a Sternberg-type working memory task during MEG. Secondarily, they completed the National Institutes of Health (NIH) cognitive toolbox. Beamforming was used to image the significant MEG oscillatory responses and the resulting images were examined using statistical parametric mapping to identify cortical activity that differed between groups.
RESULTS
Both groups had a left-lateralized decrease in alpha-beta (11-16 Hz) power across the occipital, temporal, and prefrontal cortices during encoding, as well as an increase in alpha (9-13 Hz) power across the occipital cortices during maintenance. The strength of alpha-beta oscillations in the prefrontal cortices were weaker in those with CP during encoding. Weaker alpha-beta oscillation within the prefrontal cortex was associated with poorer performance on the NIH toolbox and a higher GMFCS level.
CONCLUSIONS
Alpha-beta aberrations may impact the basic encoding of information in adults with CP, which impacts their overall cognition. Altered alpha-beta oscillation might be connected with gross motor function.
SIGNIFICANCE
This experimental work highlights the aberrant alpha-beta during encoding as possible neurophysiological mechanism of the cognitive deficiencies.
目的
本研究采用脑磁图（MEG）来确定导致脑瘫（CP）成人认知改变的神经生理机制。
方法
CP 成人（GMFCS 水平 I-IV）和年龄匹配的对照组在 MEG 期间完成 Sternberg 型工作记忆任务。其次，他们完成了美国国立卫生研究院（NIH）认知工具包。使用波束形成来成像显著的 MEG 振荡响应，并用统计参数映射来检查所得图像，以确定组间的皮质活动差异。
结果
两组在编码期间都表现出左半球枕叶、颞叶和前额叶皮质的α-β（11-16 Hz）功率降低，以及枕叶皮质α（9-13 Hz）功率增加。CP 患者在编码期间前额叶皮质的α-β振荡强度较弱。前额叶皮质中较弱的α-β 振荡与 NIH 工具包较差的表现和更高的 GMFCS 水平相关。
结论
α-β 异常可能会影响 CP 成人的基本信息编码，从而影响他们的整体认知。α-β 振荡的改变可能与粗大运动功能有关。
意义
这项实验工作强调了编码过程中异常的α-β 可能是认知缺陷的神经生理机制之一。
Zotero 插件