Faculty of Psychology and Education Sciences, University of Coimbra, Coimbra, Portugal.
BK21 PLUS Project for Medical Science, Korea.
Hum Brain Mapp. 2017 Oct;38(10):5292-5306. doi: 10.1002/hbm.23738. Epub 2017 Jul 21.
Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole-brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural-functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure-function coupling than the control group. This reduced coupling but reverse directionality in the whole-brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation-based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure-function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy. Hum Brain Mapp 38:5292-5306, 2017. © 2017 Wiley Periodicals, Inc.
脑结构网络的功能表现对于理解脑部疾病变得越来越重要。为了根据网络系统研究差异结构-功能连接，我们对比健康对照组，研究了伴有脑室周围白质软化的痉挛性双瘫脑瘫患者的脑结构和功能网络。采用弥散张量磁共振成像的确定性和概率追踪技术以及静息态功能磁共振成像的 Pearson 和偏相关分析构建了全脑和运动系统的结构和功能网络，结果显示患者的功能网络在结构网络中的嵌入程度存在差异。与健康对照组相比，患者的全脑网络结构网络中的全局网络效率显著降低，但功能网络中并未降低，导致结构-功能连接降低。相反，患者的运动网络在完整的结构网络上的功能网络效率显著降低，且结构-功能连接低于对照组。患者的全脑和运动网络中，这种降低的连接但反向的方向性在概率结构和基于偏相关的功能网络之间尤为明显。全脑的功能网络在结构网络受损的情况下相对完整（或受损较少），运动网络的功能网络拓扑结构严重受损而结构网络完整，这可能在脑瘫中起到维持相对正常认知和受损运动功能的作用。本研究表明，使用稀疏功能连接特异性评估的结构-功能关系可能为脑瘫的功能重组提供重要线索。人脑映射 38:5292-5306, 2017。© 2017 威利父子公司
