Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, 6902 Pine St, Omaha, NE 68106, United States.
Department of Physical Therapy, Creighton University, 2500 California Plz, Omaha, NE 68178, United States.
Cereb Cortex. 2024 Sep 3;34(9). doi: 10.1093/cercor/bhae365.
Our understanding of the neurobiology underlying cognitive dysfunction in persons with cerebral palsy is very limited, especially in the neurocognitive domain of visual selective attention. This investigation utilized magnetoencephalography and an Eriksen arrow-based flanker task to quantify the dynamics underlying selective attention in a cohort of youth and adults with cerebral palsy (n = 31; age range = 9 to 47 yr) and neurotypical controls (n = 38; age range = 11 to 49 yr). The magnetoencephalography data were transformed into the time-frequency domain to identify neural oscillatory responses and imaged using a beamforming approach. The behavioral results indicated that all participants exhibited a flanker effect (greater response time for the incongruent compared to congruent condition) and that individuals with cerebral palsy were slower and less accurate during task performance. We computed interference maps to focus on the attentional component and found aberrant alpha (8 to 14 Hz) oscillations in the right primary visual cortices in the group with cerebral palsy. Alpha and theta (4 to 7 Hz) oscillations were also seen in the left and right insula, and these oscillations varied with age across all participants. Overall, persons with cerebral palsy exhibit deficiencies in the cortical dynamics serving visual selective attention, but these aberrations do not appear to be uniquely affected by age.
我们对脑瘫患者认知功能障碍的神经生物学基础的理解非常有限，特别是在视觉选择性注意的神经认知领域。本研究利用脑磁图和基于 Eriksen 箭头的侧翼任务，对一组患有脑瘫的青年和成年患者（n=31；年龄范围为 9 至 47 岁）和神经典型对照组（n=38；年龄范围为 11 至 49 岁）的选择性注意的基础进行量化。脑磁图数据被转换为时频域，以识别神经振荡反应，并使用波束形成方法进行成像。行为结果表明，所有参与者都表现出侧翼效应（不一致条件下的反应时间大于一致条件下的反应时间），且脑瘫患者在任务执行过程中反应更慢且准确性更低。我们计算了干扰图以关注注意力成分，并在脑瘫组的右侧初级视觉皮层中发现了异常的 alpha（8 到 14Hz）振荡。alpha 和 theta（4 到 7Hz）振荡也出现在左右脑岛中，这些振荡在所有参与者中随年龄而变化。总体而言，脑瘫患者在视觉选择性注意的皮质动力学方面存在缺陷，但这些异常似乎不受年龄的影响。
