Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Infectious Disease Research Center, AJA University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2021 Feb 1;24(2):152-163. doi: 10.34172/aim.2021.24.
The newly emerged coronavirus disease 2019 (COVID-19) seems to involve different organs, including the cardiovascular system. We systematically reviewed COVID-19 cardiac complications and calculated their pooled incidences. Secondarily, we compared the cardiac troponin I (cTnI) level between the surviving and expired patients.
A systematic search was conducted for manuscripts published from December 1, 2019 to April 16, 2020. Cardiovascular complications, along with the levels of cTnI, creatine kinase (CK), and creatine kinase MB (CK-MB) in hospitalized PCR-confirmed COVID-19 patients were extracted. The pooled incidences of the extracted data were calculated, and the unadjusted cTnI level was compared between the surviving and expired patients.
Out of 1094 obtained records, 22 studies on a total of 4,157 patients were included. The pooled incidence rate of arrhythmia was 10.11%. Furthermore, myocardial injury had a pooled incidence of 17.85%, and finally, the pooled incidence for heart failure was 22.34%. The pooled incidence rates of cTnI, CK-MB, and CK elevations were also reported at 15.16%, 10.92%, and 12.99%, respectively. Moreover, the pooled level of unadjusted cTnI was significantly higher in expired cases compared with the surviving (mean difference = 31.818, 95% CI = 17.923-45.713, P value <0.001).
COVID-19 can affect different parts of the heart; however, the myocardium is more involved.
新出现的 2019 年冠状病毒病（COVID-19）似乎涉及包括心血管系统在内的不同器官。我们系统地回顾了 COVID-19 心脏并发症，并计算了其合并发生率。其次，我们比较了存活和死亡患者的心肌肌钙蛋白 I（cTnI）水平。
从 2019 年 12 月 1 日至 2020 年 4 月 16 日，系统地搜索了已发表的手稿。提取了住院经聚合酶链反应（PCR）确诊的 COVID-19 患者的心血管并发症以及 cTnI、肌酸激酶（CK）和肌酸激酶同工酶 MB（CK-MB）的水平。计算了提取数据的合并发生率，并比较了存活和死亡患者的未调整 cTnI 水平。
在获得的 1094 条记录中，共有 22 项研究纳入了总计 4157 例患者。心律失常的合并发生率为 10.11%。此外，心肌损伤的合并发生率为 17.85%，心力衰竭的合并发生率为 22.34%。还报告了 cTnI、CK-MB 和 CK 升高的合并发生率分别为 15.16%、10.92%和 12.99%。此外，与存活者相比，死亡者的未调整 cTnI 水平明显更高（平均差异=31.818，95%CI=17.923-45.713，P 值<0.001）。
COVID-19 可影响心脏的不同部位，但心肌受累更常见。
