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Carrying APOL1 G1 allele is associated with cardiovascular complications during COVID-19 in an admixed population.

作者信息

Cadore Nathan A, Fam Bibiana S de O, Giudicelli Giovanna C, Kowalski Thayne W, Sbruzzi Renan C, Castro E Silva Marcos A, Feira Marilea F, de Souza Célia Mariana B, da Silva Dirceu R, Artigalás Osvaldo, Lemes Renan B, Rodrigues Maíra R, Nunes Kelly, Pereira Alexandre C, Pereira Lygia V, Hünemeier Tábita, Vianna Fernanda S L

机构信息

Laboratory of Genomic Medicine, Center of Experimental Research, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.

Laboratory of Immunobiology and Immunogenetics, Graduate Program in Genetics and Molecular Biology, Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

出版信息

Hum Genomics. 2025 Aug 31;19(1):105. doi: 10.1186/s40246-025-00790-1.

DOI:10.1186/s40246-025-00790-1
PMID:40887632
Abstract
摘要

相似文献

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Carrying APOL1 G1 allele is associated with cardiovascular complications during COVID-19 in an admixed population.在一个混合人群中，携带载脂蛋白L1（APOL1）G1等位基因与新型冠状病毒肺炎（COVID-19）期间的心血管并发症相关。
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Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice.载脂蛋白L1 G1变体在载脂蛋白E基因敲除小鼠中导致脑积水，但不导致动脉粥样硬化。
bioRxiv. 2024 Dec 28:2024.12.28.630625. doi: 10.1101/2024.12.28.630625.
3
Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice.载脂蛋白-L1 G1变体在载脂蛋白E基因敲除小鼠中导致脑积水，但不导致动脉粥样硬化。
Clin Sci (Lond). 2025 May 27. doi: 10.1042/CS20255324.
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HIV-1 Nef acts in synergy with APOL1-G1 to induce nephrocyte cell death in a new model of HIV-related kidney diseases.在一种新的与HIV相关的肾脏疾病模型中，HIV-1 Nef与APOL1-G1协同作用，诱导肾细胞死亡。
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Increased prevalence of coronary heart disease among current smokers carrying APOL1 risk variants within the African American population.在非裔美国人中，携带APOL1风险变异的当前吸烟者中冠心病患病率增加。
J Clin Lipidol. 2025 Jul-Aug;19(4):1129-1138. doi: 10.1016/j.jacl.2025.04.189. Epub 2025 Apr 10.
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HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases.HIV-1 Nef与APOL1-G1协同作用，在HIV相关肾脏疾病中诱导肾细胞死亡。
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Renal and Cardiovascular Morbidities Associated with Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis.非裔美国人和非非裔美国儿童局灶节段性肾小球硬化症患者的肾脏和心血管疾病与疾病状态的相关性。
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本文引用的文献

1
Admixture's impact on Brazilian population evolution and health.混血对巴西人口演变和健康的影响。
Science. 2025 May 15;388(6748):eadl3564. doi: 10.1126/science.adl3564.
2
Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans.西非人的双等位基因和单等位基因变异与慢性肾脏病
N Engl J Med. 2025 Jan 16;392(3):228-238. doi: 10.1056/NEJMoa2404211. Epub 2024 Oct 26.
3
Clinical Characteristics and Histopathology in Adults With Focal Segmental Glomerulosclerosis.成人局灶节段性肾小球硬化的临床特征与组织病理学
Kidney Med. 2023 Nov 27;6(2):100748. doi: 10.1016/j.xkme.2023.100748. eCollection 2024 Feb.
4
Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population.特发性塌陷性肾小球病在高度混合人群中，大多数受影响个体与 APOL1 高危基因型或孟德尔变异相关。
Kidney Int. 2024 Mar;105(3):593-607. doi: 10.1016/j.kint.2023.11.028. Epub 2023 Dec 22.
5
Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.APOL1 p.N264K 变异对 G2 相关局灶节段性肾小球硬化和肾脏疾病具有强大的保护作用。
Nat Commun. 2023 Nov 30;14(1):7836. doi: 10.1038/s41467-023-43020-9.
6
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.Ⅰ型干扰素免疫基因罕见的预测性功能丧失变异与危及生命的 COVID-19 相关。
Genome Med. 2023 Apr 5;15(1):22. doi: 10.1186/s13073-023-01173-8.
7
Genetics of Chronic Kidney Disease in Low-Resource Settings.低资源环境下慢性肾脏病的遗传学研究
Semin Nephrol. 2022 Sep;42(5):151314. doi: 10.1016/j.semnephrol.2023.151314. Epub 2023 Feb 17.
8
Risk Variants and Acute Kidney Injury in Black Americans with COVID-19.美国黑人 COVID-19 患者的风险变异与急性肾损伤。
Clin J Am Soc Nephrol. 2021 Dec;16(12):1790-1796. doi: 10.2215/CJN.01070121.
9
Precision medicine implementation challenges for testing in chronic kidney disease in admixed populations.混合人群中慢性肾脏病检测的精准医学实施挑战
Front Genet. 2022 Dec 15;13:1016341. doi: 10.3389/fgene.2022.1016341. eCollection 2022.
10
Intersectional insights into racism and health: not just a question of identity.关于种族主义与健康的交叉性见解：不仅仅是身份认同问题。
Lancet. 2022 Dec 10;400(10368):2125-2136. doi: 10.1016/S0140-6736(22)02304-2.