Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA.
Department of Biology, University of Washington, Seattle, Washington 98195, USA; email:
Annu Rev Biophys. 2021 May 6;50:373-400. doi: 10.1146/annurev-biophys-110320-062613. Epub 2021 Feb 26.
Two groundbreaking papers published in 1954 laid out the theory of the mechanism of muscle contraction based on force-generating interactions between myofilaments in the sarcomere that cause filaments to slide past one another during muscle contraction. The succeeding decades of research in muscle physiology have revealed a unifying interest: to understand the multiscale processes-from atom to organ-that govern muscle function. Such an understanding would have profound consequences for a vast array of applications, from developing new biomimetic technologies to treating heart disease. However, connecting structural and functional properties that are relevant at one spatiotemporal scale to those that are relevant at other scales remains a great challenge. Through a lens of multiscale dynamics, we review in this article current and historical research in muscle physiology sparked by the sliding filament theory.
两篇具有开创性的论文于 1954 年发表，基于肌节中肌丝之间产生力的相互作用提出了肌肉收缩的机制理论，该理论认为在肌肉收缩过程中肌丝相互滑动。随后几十年的肌肉生理学研究揭示了一个统一的研究兴趣：理解从原子到器官的多尺度过程，这些过程控制着肌肉的功能。这种理解将对从开发新的仿生技术到治疗心脏病等广泛的应用产生深远的影响。然而，将在一个时空尺度上相关的结构和功能特性与在其他尺度上相关的特性联系起来仍然是一个巨大的挑战。本文通过多尺度动力学的视角，回顾了滑动丝理论引发的肌肉生理学的当前和历史研究。
