Department of Medicine, University of Washington, Seattle, Washington.
Kidney Int. 2021 Mar;99(3):542-545. doi: 10.1016/j.kint.2020.11.022.
The osteoclast proton-sensing receptors may play a role in osteoclastogenesis or bone resorption. The current study by Kreiger et al. found that in female mice, osteoclast-specific deletion of the gene for OGR1 resulted in increased bone mass, which demonstrates that in some situations this receptor is playing a role. However, there are some inconsistencies because the bone resorption was not reduced in their global knockout mice, and the effects are not seen in both genders or by other investigators. More work should be done to better define the role of OGR1 because acidosis is an important cause of bone loss.
破骨细胞质子感应受体可能在破骨细胞生成或骨吸收中发挥作用。Kreiger 等人的这项研究发现，在雌性小鼠中，破骨细胞特异性缺失 OGR1 基因导致骨量增加，这表明在某些情况下该受体发挥了作用。然而，也存在一些不一致的地方，因为它们的全球基因敲除小鼠的骨吸收并没有减少，而且这种作用在两性或其他研究人员中都没有观察到。需要进一步研究以更好地确定 OGR1 的作用，因为酸中毒是导致骨丢失的重要原因。
