Department of Speech and Hearing Sciences, Lamar University, Beaumont, TX, United States; Vision and Hearing Sciences Research Centre, School of Psychology and Sports Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
Department of Speech and Hearing Sciences, Lamar University, Beaumont, TX, United States; Department of Speech and Hearing, School of Allied Health Sciences, Manipal University, Manipal, Karnataka, India.
Prog Brain Res. 2021;260:79-99. doi: 10.1016/bs.pbr.2020.05.022. Epub 2020 Jul 24.
Tinnitus experiences differ widely. A greater understanding of the core processes underlying these variations is needed. Moreover, meaningful definitions for different subgroups are required to better manage this heterogeneous population. The objective of the present research was to contribute toward the understanding of tinnitus heterogeneity by identifying factors that can predict tinnitus severity and to ascertain if distinct subgroups of tinnitus presentation can be identified.
This cross-sectional study consisted of 326 adults subdivided into subgroups of those with mild tinnitus (n=32; 10%), significant tinnitus (n=99; 30%) and severe tinnitus (n=195; 60%) according to their scores from the Tinnitus Functional Index. Multiple regression was used to identify factors associated with tinnitus severity. These factors included personal traits, tinnitus-related traits, treatment modalities and clinical comorbidities.
Insomnia, hearing distress, and anxiety were the best predictors of tinnitus severity (explaining 53% of the variability). These comorbidities were stronger predictors than any demographical factors (that explained 11% of the variability). Distinct subgroups based on tinnitus severity (mild, significant, and severe) and anxiety levels were evident. Those with severe tinnitus had significantly more severe comorbidities compared with the mild and significant groups.
This study highlights that people with tinnitus could initially be grouped according to tinnitus severity to direct further management. Those with higher tinnitus severity should receive more immediate and intensive care. Due to the strong associations between tinnitus severity and tinnitus-related comorbidities (e.g., insomnia, hearing disability, and anxiety), tinnitus assessment and interventions should focus on these comorbidities.
耳鸣体验差异很大。需要更深入地了解这些变化背后的核心过程。此外,还需要为不同亚组提供有意义的定义,以便更好地管理这个异质人群。本研究的目的是通过确定可以预测耳鸣严重程度的因素,为理解耳鸣异质性做出贡献,并确定是否可以识别出不同的耳鸣表现亚组。
这项横断面研究包括 326 名成年人,根据他们的耳鸣功能指数评分,分为轻度耳鸣(n=32;10%)、显著耳鸣(n=99;30%)和严重耳鸣(n=195;60%)亚组。多元回归用于识别与耳鸣严重程度相关的因素。这些因素包括个人特质、耳鸣相关特质、治疗方式和临床合并症。
失眠、听力困扰和焦虑是耳鸣严重程度的最佳预测因素(解释了 53%的变异性)。这些合并症比任何人口统计学因素(解释了 11%的变异性)更能预测耳鸣严重程度。根据耳鸣严重程度(轻度、显著和严重)和焦虑水平,明显存在不同的亚组。与轻度和显著组相比,严重耳鸣患者的合并症明显更严重。
本研究表明,最初可以根据耳鸣严重程度对耳鸣患者进行分组,以指导进一步的治疗。那些耳鸣严重程度较高的患者应立即接受更密集的治疗。由于耳鸣严重程度与耳鸣相关合并症(如失眠、听力障碍和焦虑)之间存在强烈关联,因此耳鸣评估和干预应侧重于这些合并症。