Dutka A J, Kochanek P, Hallenbeck J M, Storey J R
Diving Medicine Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
Undersea Biomed Res. 1988 Mar;15(2):99-106.
The border between the gray and white matter is defined by an abrupt change in average blood flow. This difference allows one to distinguish structure with [14C]iodoantipyrine autoradiography. The angioarchitecture of the cortical gray-white junction suggests that an air embolism might preferentially lodge in this border zone, and thus ischemia of the border might go unrecognized if one depended only on the difference in average blood flow to define the gray-white junction. Accordingly, a computerized image processing technique was applied to compare the area of the cortex measured on an autoradiogram to the area measured on a histologic section after staining for myelin. In dogs that had received air embolism, the autoradiogram underestimated the thickness of the cortical mantle even in sections that did not seem to have an obvious focal zone of low blood flow. This suggests that the deep cortical layers are especially vulnerable to air embolism.
灰质和白质之间的边界由平均血流的突然变化界定。这种差异使得人们能够通过[14C]碘安替比林放射自显影术区分结构。皮质灰白质交界处的血管结构表明，空气栓塞可能优先滞留在这个边界区域，因此，如果仅依靠平均血流差异来界定灰白质交界处，边界的缺血可能无法被识别。相应地，应用计算机图像处理技术将放射自显影片上测量的皮质面积与髓磷脂染色后的组织学切片上测量的面积进行比较。在接受空气栓塞的狗中，即使在似乎没有明显低血流灶的切片中，放射自显影片也低估了皮质套的厚度。这表明皮质深层尤其易受空气栓塞影响。
