Young R S, Hernandez M J, Yagel S K
Ann Neurol. 1982 Nov;12(5):445-8. doi: 10.1002/ana.410120506.
The cerebrovascular response of newborn animals to hypotension has not been defined on a regional basis. Using an autoradiographic technique employing 14C-iodoantipyrine as indicator, we studied the cerebral physiological responses of newborn dogs to hypotension induced by exsanguination or by administration of Escherichia coli endotoxin. Regional cerebral blood flow (rCBF) to all gray matter structures was preserved, even at mean arterial pressures as low as 20 mm Hg. In contrast, rCBF to periventricular and occipital white matter decreased significantly during severe hypotension. The selective hypoperfusion of cerebral white matter during severe hypotension may provide a mechanistic explanation for the pathogenesis of periventricular leukomalacia.
新生动物对低血压的脑血管反应尚未在区域基础上得到明确界定。我们使用以14C-碘安替比林为指示剂的放射自显影技术，研究了新生犬对放血或给予大肠杆菌内毒素诱导的低血压的脑生理反应。即使在平均动脉压低至20毫米汞柱时，所有灰质结构的局部脑血流量（rCBF）仍保持不变。相比之下，在严重低血压期间，脑室周围和枕叶白质的rCBF显著下降。严重低血压期间脑白质的选择性灌注不足可能为脑室周围白质软化症的发病机制提供一个机理解释。
