Department of Medicine, Duke University School of Medicine, Durham, NC, 27705, USA.
Pflugers Arch. 2021 Mar;473(3):417-434. doi: 10.1007/s00424-021-02540-3. Epub 2021 Feb 27.
Store-operated Ca entry (SOCE) is an ancient and ubiquitous Ca signaling pathway that is present in virtually every cell type. Over the last two decades, many studies have implicated this non-voltage dependent Ca entry pathway in cardiac physiology. The relevance of the SOCE pathway in cardiomyocytes is often questioned given the well-established role for excitation contraction coupling. In this review, we consider the evidence that STIM1 and SOCE contribute to Ca dynamics in cardiomyocytes. We discuss the relevance of this pathway to cardiac growth in response to developmental and pathologic cues. We also address whether STIM1 contributes to Ca store refilling that likely impacts cardiac pacemaking and arrhythmogenesis in cardiomyocytes.
钙库操纵性钙内流（SOCE）是一种古老而普遍存在的钙信号通路，几乎存在于所有细胞类型中。在过去的二十年中，许多研究表明这种非电压依赖性钙内流途径与心脏生理学有关。鉴于兴奋-收缩偶联的作用已得到充分证实，SOCE 途径在心肌细胞中的相关性经常受到质疑。在这篇综述中，我们考虑了 STIM1 和 SOCE 对心肌细胞钙动力学的贡献的证据。我们讨论了该途径对心脏生长的相关性，以响应发育和病理线索。我们还探讨了 STIM1 是否有助于钙库再填充，这可能会影响心肌细胞中的心脏起搏和心律失常发生。
