饮食类型对 4 种犬种血液和血浆牛磺酸浓度、心脏生物标志物和超声心动图的影响。
Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds.
机构信息
University of Florida, College of Veterinary Medicine, Gainesville, Florida, USA.
Tufts University, Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA.
出版信息
J Vet Intern Med. 2021 Mar;35(2):771-779. doi: 10.1111/jvim.16075. Epub 2021 Feb 27.
BACKGROUND
Associations of diet with dilated cardiomyopathy are under investigation.
OBJECTIVES
That cardiac assessment would show abnormalities in healthy dogs eating grain-free (GF) diets or diets with Food and Drug Administration (FDA)-listed ingredients of concern (peas, lentils, or potatoes) as top 10 ingredients (FDA-PLP), but not in dogs eating grain-inclusive (GI) diets or diets without FDA-listed ingredients of concern (PLP) in the top 10 ingredients (NoFDA-PLP).
ANIMALS
One hundred eighty-eight healthy Doberman Pinschers, Golden Retrievers, Miniature Schnauzers, and Whippets.
METHODS
This study was an observational cross-sectional study. Echocardiograms, cardiac biomarkers, and blood and plasma taurine concentrations were compared between dogs eating GF (n = 26) and GI (n = 162) diets, and between FDA-PLP (n = 39) and NoFDA-PLP (n = 149) diets, controlling for age and breed. Demographic characteristics, murmurs, genetic status, and ventricular premature complexes (VPCs) during examination were compared between dogs eating different diet types.
RESULTS
No differences in echocardiographic variables, N-terminal pro-B-type natriuretic peptide or whole blood taurine were noted between dogs eating different diet types. Dogs eating GF diets had higher median high-sensitivity cardiac troponin I (hs-cTnI) (GF 0.076 ng/mL [Interquartile range (IQR), 0.028-0.156] vs. GI 0.048 [IQR, 0.0026-0.080]; P < .001) and higher median plasma taurine (GF 125 nmol/mL [IQR, 101-148] vs GI 104 [IQR, 86-123]; P = .02) than dogs eating GI diets. Dogs eating FDA-PLP diets had higher median hs-cTnI (0.059 ng/mL [IQR, 0.028-0.122]) than dogs eating NoFDA-PLP diets (0.048 [IQR, 0.025-0.085]; P = .006). A greater proportion of dogs eating FDA-PLP diets (10%) had VPCs than dogs eating NoFDA-PLP diets (2%; P = .04).
CONCLUSIONS AND CLINICAL IMPORTANCE
Higher hs-cTnI in healthy dogs eating GF and FDA-PLP diets might indicate low-level cardiomyocyte injury.
背景
人们正在研究饮食与扩张型心肌病之间的关系。
目的
心脏评估将显示食用无谷（GF）饮食或含有美国食品和药物管理局（FDA）列出的关注成分（豌豆、扁豆或土豆）作为前 10 种成分（FDA-PLP）的健康犬的心脏异常，但食用含谷物（GI）饮食或前 10 种成分中没有 FDA 列出的关注成分（PLP）的犬没有异常（NoFDA-PLP）。
动物
188 只健康的杜宾犬、金毛寻回犬、迷你雪纳瑞犬和惠比特犬。
方法
这是一项观察性的横断面研究。通过比较食用 GF（n=26）和 GI（n=162）饮食的犬，以及食用 FDA-PLP（n=39）和 NoFDA-PLP（n=149）饮食的犬之间的超声心动图、心脏生物标志物以及血液和血浆牛磺酸浓度，控制年龄和品种。比较食用不同饮食类型的犬之间的人口统计学特征、杂音、遗传状况和检查期间的室性期前收缩（VPC）。
结果
食用不同饮食类型的犬之间的超声心动图变量、N 端脑利钠肽前体或全血牛磺酸无差异。食用 GF 饮食的犬的中位高敏心肌肌钙蛋白 I（hs-cTnI）较高（GF 0.076ng/mL[四分位距（IQR），0.028-0.156] vs.GI 0.048ng/mL[IQR，0.0026-0.080]；P<0.001），血浆牛磺酸中位值较高（GF 125nmol/mL[IQR，101-148] vs.GI 104nmol/mL[IQR，86-123]；P=0.02），高于食用 GI 饮食的犬。食用 FDA-PLP 饮食的犬的中位 hs-cTnI（0.059ng/mL[IQR，0.028-0.122]）高于食用 NoFDA-PLP 饮食的犬（0.048ng/mL[IQR，0.025-0.085]；P=0.006）。食用 FDA-PLP 饮食的犬中有更大比例（10%）出现 VPC，高于食用 NoFDA-PLP 饮食的犬（2%；P=0.04）。
结论和临床意义
食用 GF 和 FDA-PLP 饮食的健康犬的 hs-cTnI 升高可能表明存在低水平的心肌细胞损伤。
Zotero 插件