LPP, UMR 7018, CNRS/University Sorbonne-Nouvelle, Paris, France.
APHP, Department of Neurology, Pitié-Salpêtrière Hospital, ALS Reference Center, France.
J Acoust Soc Am. 2021 Feb;149(2):758. doi: 10.1121/10.0003332.
Identifying characteristics of articulatory impairment in speech motor disorders is complicated due to the time-consuming nature of kinematic measures. The goal is to explore whether analysing the acoustic signal in terms of total squared changes of Mel-Frequency Cepstral Coefficients (TSC_MFCC) and its pattern over time provides sufficient spectral information to distinguish mild and moderate dysarthric French speakers with Amyotrophic Lateral Sclerosis (ALS) and Parkinson's Disease (PD) from each other and from healthy speakers. Participants produced the vowel-glide sequences /ajajaj/, /ujujuj/, and /wiwiwi/. From the time course of TSC_MFCCs, event-related and global measures were extracted to capture the degree of acoustic change and its variability. In addition, durational measures were obtained. For both mild and moderately impaired PD and ALS speakers, the degree of acoustic change and its variability, averaged over the complete contour, separated PD and ALS speakers from each other and from healthy speakers, especially when producing the sequences /ujujuj/ and /wiwiwi/. Durational measures separated the moderate ALS from healthy and moderate PD speakers. Using the approach on repetitive sequences targeting the lingual and labial articulators to characterize articulatory impairment in speech motor disorders is promising. Findings are discussed against prior findings of articulatory impairment in the populations studied.
由于运动学测量具有耗时的特点,因此识别言语运动障碍中发音障碍的特征较为复杂。目的是探索分析声学信号在梅尔频率倒谱系数总平方变化(TSC_MFCC)及其随时间的变化模式方面是否提供了足够的频谱信息,以区分轻度和中度构音障碍的法国肌萎缩侧索硬化症(ALS)和帕金森病(PD)患者与健康说话者。参与者发出元音滑音序列 /ajajaj/、/ujujuj/ 和 /wiwiwi/。从 TSC_MFCC 的时间过程中,提取了与事件相关和全局的测量值,以捕获声学变化的程度及其可变性。此外,还获得了时长测量值。对于轻度和中度受损的 PD 和 ALS 患者,平均整个轮廓的声学变化程度及其可变性将 PD 和 ALS 患者彼此以及与健康说话者区分开来,尤其是在产生序列 /ujujuj/ 和 /wiwiwi/ 时。时长测量值将中度 ALS 与健康和中度 PD 患者区分开来。使用针对舌和唇发音器的重复序列方法来描述言语运动障碍中的发音障碍是有前景的。研究结果将根据研究人群中的发音障碍先前发现进行讨论。