Department of Ophthalmology, Beijing Chaoyang Hospital, the Third Clinical Medical College of Capital Medical University, No. 8, Worker's stadium south road, Chaoyang District, Beijing, 100020, PR China.
BMC Ophthalmol. 2021 Feb 27;21(1):108. doi: 10.1186/s12886-021-01860-3.
This study aims to compare the levels of intraocular cytokines between Fuchs uveitis syndrome (FUS) eyes and the senile cataract eyes. The association between inflammatory cytokine levels and cataract severity in FUS is evaluated to find the possible mechanism of cataract in FUS eyes.
A retrospective study of 28 eyes with FUS was performed. Auxiliary examinations were performed, including ophthalmic examinations, laser flare-cell photometry, and levels of inflammatory cytokines in the aqueous humor were measured. The control group included 25 eyes with senile cataract. Data on the aqueous humor inflammatory cytokines were compared between the two groups. The association between the aqueous humor cytokine levels and severity of posterior subcapsular cataract was assessed.
There were 28 eyes with FUS in 27 patients. Unilateral involvement was noted in 26 patients (96.30%). Stellate keratic precipitates (KPs) were noted in 16 eyes (57.14%). Heterochromia was observed in 21.43% of affected eyes. Posterior subcapsular cataract (PSC) was observed in 16 of the 28 eyes. Eyes with FUS had significantly higher aqueous humor (AH) cytokine levels (VEGF, bFGF, IL-6, IL-8 and IL-10) compared with the control eyes (P < 0.05). There was a statistically significant positive correlation between the severity of cataract and IL-6 and IL-8 levels in the AH (τ = 0.664 and 0.634, respectively; P = 0.001, P = 0.002, respectively).
Expression of VEGF, bFGF, IL-6, IL-8 and IL-10 in the AH of FUS patients was significantly higher than in senile cataract eyes, and the aqueous humor levels of IL-6 and IL-8 were significantly positively associated with the severity of posterior subcapsular cataract. Our results imply that an inflammation mechanism may be involved in the early development of cataract in FUS.
本研究旨在比较 Fuchs 葡萄膜炎综合征（FUS）眼和老年性白内障眼中的眼内细胞因子水平。评估 FUS 中炎症细胞因子水平与白内障严重程度之间的关系，以寻找 FUS 眼中白内障的可能机制。
对 28 只 FUS 眼进行回顾性研究。进行辅助检查，包括眼科检查、激光闪烁细胞光度测定和房水中炎症细胞因子水平的测量。对照组包括 25 只老年性白内障眼。比较两组房水炎症细胞因子数据。评估房水细胞因子水平与后囊下白内障严重程度的关系。
27 例患者共 28 只眼患有 FUS，单侧受累 26 例（96.30%）。16 只眼（57.14%）出现星状角膜后沉着物（KP）。受影响眼中 21.43%存在虹膜异色。28 只眼中 16 只患有后囊下白内障。与对照组相比，FUS 眼房水中的细胞因子水平（VEGF、bFGF、IL-6、IL-8 和 IL-10）显著升高（P<0.05）。白内障严重程度与房水中 IL-6 和 IL-8 水平呈显著正相关（τ=0.664 和 0.634，P=0.001，P=0.002）。
FUS 患者房水中 VEGF、bFGF、IL-6、IL-8 和 IL-10 的表达明显高于老年性白内障眼，房水中 IL-6 和 IL-8 水平与后囊下白内障的严重程度呈显著正相关。我们的结果表明，炎症机制可能参与了 FUS 中白内障的早期发展。
