在巴西亚马孙州玛瑙斯市的 Alfredo da Matta 基金会就诊的 170 名尿道炎男性患者中，确定的主要病因。
Main etiological agents identified in 170 men with urethritis attended at the Fundação Alfredo da Matta, Manaus, Amazonas, Brazil.
机构信息
Department of Sexually Transmitted Infections, Fundação Alfredo da Matta, Manaus, AM, Brazil.
Department of Dermatology, Universidade do Estado do Amazonas, Manaus, AM, Brazil.
出版信息
An Bras Dermatol. 2021 Mar-Apr;96(2):176-183. doi: 10.1016/j.abd.2020.07.007. Epub 2021 Jan 31.
BACKGROUND
Sexually transmitted infections (STI) are a global public health problem. Urethritis are among the most common STIs, and can cause several complications and facilitate the transmission of the HIV virus.
OBJECTIVES
To investigate the main etiologic agents of urethritis in 170 men treated at Fundação Alfredo da Matta.
METHODS
To identify the agents, urethral exudate and urine were collected. Gram and culture tests were performed in Thayer-Martin medium for Neisseria gonorrhoeae and polymerase chain reaction for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, Mycoplasma genitalium, and herpes simplex types 1 and 2.
RESULTS
N. gonorrhoeae were identified in 102 (60.0%) patients, C. trachomatis in 50 (29.4%), U. urealyticum in 29 (17.0%), M. genitalium in 11 (6.5 %), U. parvum in ten (5.9%), and M. hominis in seven (4.1%). Herpes simplex type 2 was diagnosed in 24 (21.6%) of the 111 patients who underwent PCR for this pathogen. In 69 cases there was co-infection; the most frequent were: N. gonorrhoeae and C. trachomatis in 21 (14.7%) patients; N. gonorrhoeae and C. trachomatis in 21 (12.4%) patients; N. gonorrhoeae and herpes simplex type 2 in 11 (6.5%), and N. gonorrhoeae and U. urealyticum in nine (5.3%).
STUDY LIMITATIONS
Not relevant.
CONCLUSION
N. gonorrhoeae, C. trachomatis, U. urealyticum, and herpes simplex type 2 were the pathogens most frequently identified in the present study. The main coinfection found was N. gonorrhoeae and C. trachomatis. T. vaginalis and herpes simplex type 1 were not identified in any of the patients.
背景
性传播感染（STI）是全球公共卫生问题。尿道炎是最常见的 STI 之一，可引起多种并发症并促进 HIV 病毒的传播。
目的
调查在 Alfredo da Matta 基金会接受治疗的 170 名男性尿道炎的主要病原体。
方法
为了确定病原体，采集尿道分泌物和尿液。在 Thayer-Martin 培养基中进行革兰氏染色和培养试验，用于淋病奈瑟菌和淋病奈瑟菌的聚合酶链反应，用于沙眼衣原体、阴道毛滴虫、解脲脲原体、解脲脲原体、人型支原体、生殖支原体和单纯疱疹病毒 1 型和 2 型。
结果
102 例（60.0%）患者中发现淋病奈瑟菌，50 例（29.4%）患者中发现沙眼衣原体，29 例（17.0%）患者中发现解脲脲原体，11 例（6.5%）患者中发现生殖支原体，10 例（5.9%）患者中发现微小脲原体，7 例（4.1%）患者中发现人型支原体。在接受单纯疱疹病毒 2 型 PCR 检测的 111 例患者中，诊断出 24 例（21.6%）单纯疱疹病毒 2 型感染。69 例患者存在合并感染；最常见的合并感染是淋病奈瑟菌和沙眼衣原体，21 例（14.7%）患者；淋病奈瑟菌和沙眼衣原体，21 例（12.4%）患者；淋病奈瑟菌和单纯疱疹病毒 2 型，11 例（6.5%）患者；淋病奈瑟菌和解脲脲原体，9 例（5.3%）患者。
研究局限性
不相关。
结论
淋病奈瑟菌、沙眼衣原体、解脲脲原体和单纯疱疹病毒 2 型是本研究中最常发现的病原体。发现的主要合并感染是淋病奈瑟菌和沙眼衣原体。阴道毛滴虫和单纯疱疹病毒 1 型在任何患者中均未发现。
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