解脲脲原体诱导多形核弹性蛋白酶改变精液特性并降低精子活力：一项前瞻性观察性研究。
Ureaplasma urealyticum induces polymorphonuclear elastase to change semen properties and reduce sperm motility: a prospective observational study.
机构信息
The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Department of Andrology, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou, Guangdong Province, China.
出版信息
J Int Med Res. 2022 Jun;50(6):3000605221106410. doi: 10.1177/03000605221106410.
OBJECTIVE
To elucidate the mechanism underlying how (UU) affects sperm quality and identify a therapeutic target.
METHODS
In this prospective observational study, the differences in and relationships among semen volume, pH, viscosity, liquefaction time, sperm concentration, sperm motility [progressive motility (PR)], and seminal polymorphonuclear (PMN) elastase were analyzed in 198 normal semen samples (control group) and 198 UU-infected semen samples (observation group). The UU-infected samples were treated and the above parameters were compared between the two groups.
RESULTS
The semen volume, viscosity, liquefaction time, and seminal PMN elastase were significantly higher in the observation than control group, but the pH and PR were significantly lower. In the observation group, the pH and PR were significantly higher after than before treatment, whereas the semen volume, PMN elastase, viscosity, and liquefaction time were lower. UU was closely related to semen volume, pH, viscosity, liquefaction time, sperm motility (PR), and PMN elastase. PMN elastase had significant negative effects on semen pH and sperm motility (PR) but positive effects on viscosity and liquefaction time.
CONCLUSION
UU might induce PMN elastase to increase the liquefaction time and viscosity of semen, eventually decreasing PR. PMN elastase might be a therapeutic target of UU.
目的
阐明解脲脲原体（UU）影响精子质量的机制，并确定治疗靶点。
方法
本前瞻性观察性研究分析了 198 例正常精液样本（对照组）和 198 例 UU 感染精液样本（观察组）的精液量、pH 值、黏度、液化时间、精子浓度、精子活力[前向运动（PR）]和精液多形核（PMN）弹性蛋白酶的差异和关系。对 UU 感染样本进行治疗，并比较两组之间的上述参数。
结果
观察组的精液量、黏度、液化时间和PMN 弹性蛋白酶显著高于对照组，而 pH 值和 PR 显著低于对照组。观察组治疗后 pH 值和 PR 显著高于治疗前，而精液量、PMN 弹性蛋白酶、黏度和液化时间则降低。UU 与精液量、pH 值、黏度、液化时间、精子活力（PR）和PMN 弹性蛋白酶密切相关。PMN 弹性蛋白酶对精液 pH 值和精子活力（PR）有显著的负向影响，但对黏度和液化时间有正向影响。
结论
UU 可能诱导PMN 弹性蛋白酶增加精液的液化时间和黏度，最终降低 PR。PMN 弹性蛋白酶可能是 UU 的治疗靶点。
Zotero 插件