State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, PR China.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, PR China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211800, PR China.
Biotechnol Adv. 2021 May-Jun;48:107724. doi: 10.1016/j.biotechadv.2021.107724. Epub 2021 Feb 25.
Biofilms can be naturally formed through the attachment of microorganisms on the supporting materials. However, natural biofilms formed in the environment may cause some detrimental effects, such as the equipment contamination and food safety issues et al. On the contrary, biofilms mediated microbial fermentation provides a promising approach for the efficient biochemicals production owing to the properties of self-immobilization, high resistance to toxic reactants and maintenance of long-term cells activity. While few reviews have specifically addressed the biological application of biofilms in the microbial fermentation process. Accordingly, this review will comprehensively summarize the biofilms formation mechanism and potential functions in the microbial fermentation process. Furthermore, the construction strategies for the formation of stable biofilms through synthetic biology technology or the modification of suitable supporting materials will be also discussed. The application of biofilms mediated fermentation will provide an outlook for the biorefinery platform in the future.
生物膜可以通过微生物在支撑材料上的附着自然形成。然而，在环境中形成的天然生物膜可能会产生一些有害影响，例如设备污染和食品安全问题等。相反，生物膜介导的微生物发酵为高效生化制品的生产提供了一种很有前途的方法，因为它具有自我固定、对有毒反应物的高抗性和长期保持细胞活性的特性。然而，很少有综述专门针对生物膜在微生物发酵过程中的生物学应用进行讨论。因此，本综述将全面总结生物膜在微生物发酵过程中的形成机制和潜在功能。此外，还将讨论通过合成生物学技术或适当支撑材料的修饰来构建稳定生物膜的构建策略。生物膜介导发酵的应用将为未来的生物炼制平台提供一个展望。
