Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Department of Cardiac Electrophysiology, The Mount Sinai Hospital, New York, New York.
Heart Rhythm. 2021 Jul;18(7):1223-1229. doi: 10.1016/j.hrthm.2021.02.017. Epub 2021 Feb 25.
Our knowledge of associated cardiotoxicities from novel therapeutics in oncology continues to expand. These include arrhythmias from cancer-therapy induced cardiomyopathy resulting from both direct and indirect effects on cardiomyocytes and other mechanisms that can adversely impact cardiovascular outcomes and overall mortality. In this review, we focus on both the arrhythmias of various classes of oncologic agents as well as the use of cardiac implantable electronic devices (cardioverter-defibrillators, permanent pacemakers, and cardiac resynchronization therapy) in cardio-oncology patients.
我们对肿瘤新型治疗药物相关心脏毒性的认识不断扩展。这些毒性包括癌症治疗引起的心肌病导致的心律失常,其原因包括对心肌细胞的直接和间接影响以及其他可能对心血管结局和总体死亡率产生不利影响的机制。在本综述中,我们重点讨论了各种肿瘤药物的心律失常,以及心脏植入式电子设备(除颤器、永久性起搏器和心脏再同步治疗)在心脏肿瘤患者中的应用。