Hawryszko Maja, Sławiński Grzegorz, Tomasik Bartłomiej, Lewicka Ewa
Department of Cardiology and Heart Electrotherapy, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17 Street, 80-214 Gdansk, Poland.
Cancers (Basel). 2023 Dec 6;15(24):5723. doi: 10.3390/cancers15245723.
Cardio-oncology currently faces one of the greatest challenges in the field of health care. The main goal of this discipline is to ensure that patients treated for cancer do not suffer or die from cardiovascular disease. The number of studies on the mechanisms of heart injury during cancer treatment is constantly increasing. However, there is insufficient data on heart rhythm disorders that may result from this treatment. This issue seems to be particularly important in patients with lung cancer, in whom anticancer therapy, especially radiotherapy, may contribute to the onset of cardiac arrhythmias. The observed relationship between cardiac dosimetry and radiotherapy-induced cardiotoxicity in lung cancer treatment may explain the increased mortality from cardiovascular causes in patients after chest irradiation. Further research is essential to elucidate the role of cardiac arrhythmias in this context. Conversely, recent reports have highlighted the application of stereotactic arrhythmia radioablation (STAR) in the treatment of ventricular tachycardia. This review of available studies on the epidemiology, pathogenesis, diagnosis, and treatment of arrhythmias in patients treated for lung cancer aims to draw attention to the need for regular cardiological monitoring in this group of patients. Improving cardiac care for patients with lung cancer has the potential to enhance their overall therapeutic outcomes.
心脏肿瘤学目前面临着医疗保健领域最大的挑战之一。该学科的主要目标是确保接受癌症治疗的患者不会因心血管疾病而受苦或死亡。关于癌症治疗期间心脏损伤机制的研究数量在不断增加。然而,关于这种治疗可能导致的心律失常的数据不足。这个问题在肺癌患者中似乎尤为重要,在这些患者中,抗癌治疗,尤其是放疗,可能会导致心律失常的发生。在肺癌治疗中观察到的心脏剂量测定与放疗诱发的心脏毒性之间的关系,可能解释了胸部放疗后患者心血管原因导致的死亡率增加。进一步的研究对于阐明心律失常在这种情况下的作用至关重要。相反,最近的报告强调了立体定向心律失常射频消融术(STAR)在室性心动过速治疗中的应用。这篇对肺癌治疗患者心律失常的流行病学、发病机制、诊断和治疗的现有研究综述旨在提请人们注意这组患者定期进行心脏监测的必要性。改善肺癌患者的心脏护理有可能提高他们的整体治疗效果。