Froster-Iskenius U, Klink F, Grzejszczyk G, Sömmer F, Schwinger E, Oberheuser F
Klinik für Frauenheilkunde und Geburtshilfe, Medizinischen Universität zu Lübeck.
Zentralbl Gynakol. 1988;110(3):146-57.
Chorion villi biopsy is a recently introduced method for first trimester prenatal diagnosis. Based on 435 cases of chorionic villi biopsies, obtained during a 3 year period, we report our experiences with the technique of chorionic villi sampling, chromosomal analysis from trophoblast tissue and possibly associated complications, such as spontaneous abortions, vaginal bleeding, and chromosomal mosaicism. The rate of spontaneous abortions in our group of patients was 3%. This appears low, considering the high overall spontaneous abortion rate in early pregnancy of women over 35 years. The cytogenetic diagnosis is complicated by a high rate (2.8%) of chromosomal mosaicism, which were found to be not representative for the fetus, but required control amniocentesis. From our experiences with this method we conclude that chorion villi biopsy can be offered as a reliable alternative method to amniocentesis in the hands of an experienced team of obstetric surgeons and cytogenetists.
绒毛膜绒毛活检是一种最近引入的孕早期产前诊断方法。基于3年期间获得的435例绒毛膜绒毛活检病例，我们报告了我们在绒毛膜绒毛取样技术、滋养层组织染色体分析以及可能相关的并发症（如自然流产、阴道出血和染色体嵌合体）方面的经验。我们这组患者的自然流产率为3%。考虑到35岁以上女性早期妊娠的总体自然流产率较高，这个数字似乎较低。细胞遗传学诊断因高比例（2.8%）的染色体嵌合体而变得复杂，这些嵌合体被发现不代表胎儿情况，但需要进行羊水穿刺检查。根据我们使用这种方法的经验，我们得出结论，在经验丰富的产科外科医生和细胞遗传学家团队手中，绒毛膜绒毛活检可以作为羊水穿刺的可靠替代方法。
