Manolova E P, Tret'iakevich Z N, Khripko S V, Mechetnaia I N
Zh Mikrobiol Epidemiol Immunobiol. 1988 Jan(1):49-51.
The possibility of enhancing specific immunity by the oral administration of homologous antistaphylococcal immunoglobulin in a dose of 50 I. U./kg b. w. before the first feeding was shown in 75 newborn infants with a high risk of staphylococcal infection. 24 hours after the first administration of Ig the titer of staphylococcal anti-alpha toxin in the blood rose from 0.68 +/- 0.05 I. U./ml to 2.9 +/- 0.14 I. U/ml, on day 7 this titer persisted at the level of 2.86 +/- 0.12 I. U./ml, and 3 months later the titer was 1.5 +/- 0.05 I. U./ml. No side effects were observed. In the reference group (50 infants) antitoxic titers remained low. No suppurative-septic diseases were observed in the test group within 3 months, while in the controls, focal forms of staphylococcal infection (12 cases) and sepsis (1 case) were registered.
在75名有葡萄球菌感染高风险的新生儿中，研究显示在首次喂养前口服剂量为50国际单位/千克体重的同源抗葡萄球菌免疫球蛋白可增强特异性免疫力。首次给予免疫球蛋白24小时后，血液中葡萄球菌抗α毒素的滴度从0.68±0.05国际单位/毫升升至2.9±0.14国际单位/毫升，第7天该滴度维持在2.86±0.12国际单位/毫升的水平，3个月后滴度为1.5±0.05国际单位/毫升。未观察到副作用。在参照组（50名婴儿）中，抗毒素滴度仍较低。在3个月内，试验组未观察到化脓性败血症疾病，而在对照组中，记录到了葡萄球菌感染的局灶性形式（12例）和败血症（1例）。
