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Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44-ENaC signal cascade.

作者信息

Ali Gibran, Zhang Mo, Zhao Runzhen, Jain Krishan G, Chang Jianjun, Komatsu Satoshi, Zhou Beiyun, Liang Jiurong, Matthay Michael A, Ji Hong-Long

机构信息

Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX, USA.

Institute of Lung and Molecular Therapy, Xinxiang Medical University, Xinxiang, Henan, China.

出版信息

Signal Transduct Target Ther. 2021 Feb 27;6(1):97. doi: 10.1038/s41392-021-00511-9.

DOI:10.1038/s41392-021-00511-9
PMID:33640905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910758/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e1/7914251/aa901fbd8023/41392_2021_511_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e1/7914251/aa901fbd8023/41392_2021_511_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51e1/7914251/aa901fbd8023/41392_2021_511_Fig1_HTML.jpg

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Br J Pharmacol. 2020 Jul;177(13):3091-3106. doi: 10.1111/bph.15038. Epub 2020 May 11.
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Proliferative regulation of alveolar epithelial type 2 progenitor cells by human gene.人基因对肺泡上皮 2 型祖细胞的增殖调控。
Theranostics. 2019 Oct 18;9(26):8155-8170. doi: 10.7150/thno.37023. eCollection 2019.
3
Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
可吸入黏液穿透脂质纳米粒复张术治疗小鼠肺纤维化。
Sci Adv. 2024 Jun 14;10(24):eado4791. doi: 10.1126/sciadv.ado4791. Epub 2024 Jun 12.
4
Alveolar Type 2 Epithelial Cell Organoids: Focus on Culture Methods.肺泡II型上皮细胞类器官:聚焦培养方法
Biomedicines. 2023 Nov 12;11(11):3034. doi: 10.3390/biomedicines11113034.
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Repairing Mechanisms for Distal Airway Injuries and Related Targeted Therapeutics for Chronic Lung Diseases.远端气道损伤的修复机制及慢性肺部疾病的相关靶向治疗。
Cell Transplant. 2023 Jan-Dec;32:9636897231196489. doi: 10.1177/09636897231196489.
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