远端气道损伤的修复机制及慢性肺部疾病的相关靶向治疗。
Repairing Mechanisms for Distal Airway Injuries and Related Targeted Therapeutics for Chronic Lung Diseases.
机构信息
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, China.
出版信息
Cell Transplant. 2023 Jan-Dec;32:9636897231196489. doi: 10.1177/09636897231196489.
Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), involve progressive and irreversible destruction and pathogenic remodeling of airways and have become the leading health care burden worldwide. Pulmonary tissue has extensive capacities to launch injury-responsive repairing programs (IRRPs) to replace the damaged or dead cells upon acute lung injuries. However, the IRRPs are frequently compromised in chronic lung diseases. In this review, we aim to provide an overview of somatic stem cell subpopulations within distal airway epithelium and the underlying mechanisms mediating their self-renewal and trans-differentiation under both physiological and pathological circumstances. We also compared the differences between humans and mice on distal airway structure and stem cell composition. At last, we reviewed the current status and future directions for the development of targeted therapeutics on defective distal airway regeneration and repairment in chronic lung diseases.
慢性肺部疾病，如慢性阻塞性肺疾病（COPD）和特发性肺纤维化（IPF），涉及气道的进行性和不可逆转的破坏和病理性重塑，已成为全球主要的医疗保健负担。肺部组织具有广泛的能力来启动损伤反应性修复程序（IRRPs），以在急性肺损伤后替代受损或死亡的细胞。然而，IRRPs 在慢性肺部疾病中经常受到损害。在这篇综述中，我们旨在概述远端气道上皮中的体干细胞亚群，以及在生理和病理情况下介导其自我更新和转分化的潜在机制。我们还比较了人类和小鼠在远端气道结构和干细胞组成上的差异。最后，我们回顾了针对慢性肺部疾病中缺陷性远端气道再生和修复的靶向治疗的现状和未来方向。
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