Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
J Int Med Res. 2021 Feb;49(2):300060521990992. doi: 10.1177/0300060521990992.
The present study aimed to investigate patients' characteristics that can affect the dose of propofol required to sedate children undergoing imaging.
In this retrospective, observational study, we reviewed medical records of children aged 0 to 18 years who were classified as having American Society of Anesthesiologists status 1 or 2 and they underwent imaging under propofol sedation between January 2011 and August 2016. Collected data included patients' demographics, propofol doses, duration of sedation, and complications. Regression analysis was performed to determine patients' characteristics that may affect the dose of propofol required to induce sedation.
A total of 925 patients were included. Simple linear regression showed that the dose of propofol was correlated with age, height, weight, and body surface area. Using the results of multiple linear regression, the following formula was used to estimate the dose of propofol (mg) for sedation: 0.75 + 0.14 × age (months) + 45.82 × body surface area (m).
A child's age, height, and body surface area should be considered when deciding the induction dose of propofol. Additionally, the formula that we have proposed can be used to estimate the dose of propofol required to induce sedation in children undergoing imaging.
本研究旨在探讨影响行影像学检查的儿童所需异丙酚镇静剂量的患者特征。
在这项回顾性观察研究中，我们回顾了 2011 年 1 月至 2016 年 8 月期间接受异丙酚镇静下影像学检查的年龄在 0 至 18 岁、ASA 分级为 1 级或 2 级的儿童的病历。收集的数据包括患者的人口统计学资料、异丙酚剂量、镇静持续时间和并发症。采用回归分析确定可能影响诱导镇静所需异丙酚剂量的患者特征。
共纳入 925 例患者。简单线性回归显示，异丙酚剂量与年龄、身高、体重和体表面积相关。使用多元线性回归的结果，得出了用于估计镇静所需异丙酚剂量（mg）的公式：0.75+0.14×年龄（月）+45.82×体表面积（m）。
在决定异丙酚诱导剂量时，应考虑儿童的年龄、身高和体表面积。此外，我们提出的公式可用于估计行影像学检查的儿童所需的异丙酚镇静诱导剂量。
