Department of Internal Medicine, Taipei City Hospital, Taipei, Taiwan.
Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Expert Rev Anti Infect Ther. 2021 Sep;19(9):1093-1098. doi: 10.1080/14787210.2021.1892488. Epub 2021 Mar 1.
: Tuberculosis, a chronic infection caused by Mycobacterium tuberculosis (MTB), is one of the 10 leading causes of death in the world. The current treatment is a combination antimicrobial therapy administered for 6-9 months. It is important to find therapeutic strategy to shorten the treatment during and strengthen the host immune response against MTB.: There is evidence that MTB uses cholesterol in the host macrophage to infect and survive inside the host macrophage. Statins inhibit the synthesis of cholesterol and aid in reducing the levels of cholesterol in human, which have been associated with better outcome in infectious diseases. In this narrative review, we discuss recent studies that investigated the effects of statins on the prevention or treatment of TB infection.: The evaluation of the published evidence suggests that statins may be beneficial in the treatment of patients with TB infections. Future studies may focus not only on the beneficial effects of statins, but also on distinguishing the effects of different statins.
: 结核病是由结核分枝杆菌（MTB）引起的慢性感染，是世界上十大死亡原因之一。目前的治疗方法是联合使用抗菌药物进行 6-9 个月的治疗。寻找一种既能缩短治疗时间又能增强宿主对 MTB 免疫反应的治疗策略非常重要。有证据表明，MTB 利用宿主巨噬细胞中的胆固醇来感染和在宿主巨噬细胞内生存。他汀类药物抑制胆固醇的合成，并有助于降低人体内胆固醇的水平，这与传染病的更好结局有关。在这篇叙述性综述中，我们讨论了最近研究他汀类药物对预防或治疗 TB 感染的影响。: 对已发表证据的评估表明，他汀类药物可能对治疗 TB 感染患者有益。未来的研究不仅可以关注他汀类药物的有益作用，还可以区分不同他汀类药物的作用。
