Banerjee Dibyajyoti, Bhattacharyya Rajasri
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, India.
Med Hypotheses. 2014 Jul;83(1):88-91. doi: 10.1016/j.mehy.2014.04.002. Epub 2014 Apr 13.
Host cholesterol is widely getting recognized as an important factor in the pathogenesis of tuberculosis in multiple ways. Therefore it is logically expected that cholesterol reduction by statins is going to have a positive outcome in the context of tuberculosis management. But at the present moment statin therapy in non diabetic individuals is believed to pose a small risk for development of diabetes mellitus, a prevalent disease throughout the globe that is known to be associated with tuberculosis infection. Consequently, in diabetic individuals statins are commonly prescribed drugs for multiple positive outcomes. Therefore it seems that statin therapy in diabetes mellitus has the potential to prevent the increased occurrence of tuberculosis in diabetic state.
宿主胆固醇在结核病发病机制的多个方面被广泛认为是一个重要因素。因此，从逻辑上讲，可以预期他汀类药物降低胆固醇在结核病管理方面会产生积极效果。但目前，非糖尿病个体使用他汀类药物治疗被认为有患糖尿病的小风险，糖尿病是全球一种普遍的疾病，已知与结核感染有关。因此，在糖尿病个体中，他汀类药物是常用于产生多种积极效果的药物。所以，糖尿病患者使用他汀类药物治疗似乎有可能预防糖尿病状态下结核病发病率的增加。
