Finnie J W, O'Shea J D
Department of Agriculture and Rural Affairs, University of Melbourne, Parkville, Victoria, Australia.
Acta Neuropathol. 1988;75(4):411-21. doi: 10.1007/BF00687795.
Guinea pigs were injected with tunicamycin and the sequential morphological alterations in the brain examined to investigate further the pathogenesis of cerebral lesions in this experimental model of annual ryegrass toxicity, a central nervous system disease of livestock caused by members of the tunicamycin group of antibiotics. Brain damage was most commonly observed in the cerebellum, and the important alterations in the development of degenerative parenchymal lesions appeared to be largely referrable to changes in small blood vessels. Endothelial damage, with increased vascular permeability, resulted in capillary obstruction leading to localised ischaemia and hypoxic neuronal damage. There was evidence for several possible mechanisms which may have contributed to vascular occlusion.
给豚鼠注射衣霉素，并检查大脑中连续的形态学变化，以进一步研究在这种一年生黑麦草中毒实验模型中脑损伤的发病机制，一年生黑麦草中毒是一种由衣霉素类抗生素引起的家畜中枢神经系统疾病。脑损伤最常出现在小脑，实质性退行性病变发展过程中的重要变化似乎主要与小血管的改变有关。内皮损伤伴血管通透性增加，导致毛细血管阻塞，进而引起局部缺血和缺氧性神经元损伤。有证据表明几种可能导致血管闭塞的机制。
