Finnie J W, Mukherjee T M
J Comp Pathol. 1986 Mar;96(2):205-16. doi: 10.1016/0021-9975(86)90011-3.
Nursling rats were given a lethal dose of corynetoxin and the sequential morphological alterations in the cerebellum were examined at daily intervals up to 3 days post-inoculation. Ultrastructural changes were those of cerebral vascular damage, which was usually focal in affected endothelial cells, and resulted in vascular stasis or thrombosis. These changes ultimately constituted a failure of perfusion in focal areas of brain parenchyma supplied by these vessels, resulting in necrosis.
给乳鼠注射致死剂量的棒状杆菌毒素，在接种后长达3天的时间里，每天对小脑的连续形态学改变进行检查。超微结构变化表现为脑血管损伤，这种损伤通常局限于受影响的内皮细胞，导致血管淤滞或血栓形成。这些变化最终导致由这些血管供应的脑实质局部区域灌注失败，从而引起坏死。
