Eberhard Karls University Tuebingen, Tuebingen, Germany.
Nutr Neurosci. 2022 Sep;25(9):1785-1795. doi: 10.1080/1028415X.2021.1888205. Epub 2021 Feb 28.
We performed random effects meta-analysis We computed a weighted effect size (Hedges' g) for the difference of the absolute scores of the Hamilton Depression Rating Scale between the group given zinc and the group given placebo after 6 and after 12 weeks. We performed subgroup analysis according to whether not it was stated in the original studies that patients in a clinical trial or subgroup within a trial had not reached remission with previous treatment with a standard antidepressant during the same illness episode. After 6 weeks, we obtained the following effect sizes: Overall effect size: Hedges' = -0.67, = 0.03. Subgroup with documented non-remission: Hedges' = - 0.97, = 0.001. Group without documented non-remission -0.35, = 0.24. After 12 weeks: Overall effect size: Hedges' = -1.0, = 0.03. Subgroup with documented non-remission: Hedges' = - 1.46, < 0.001. Group without documented non-remission: Hedges' = - 0.54, = 0.07.
We provide preliminary evidence for the efficacy of zinc vs. placebo as an adjunct to antidepressant medication.
我们进行了随机效应荟萃分析，计算了给予锌组和给予安慰剂组在 6 周和 12 周后汉密尔顿抑郁评定量表绝对评分差值的加权效应量（Hedges'g）。我们根据原始研究中是否说明临床试验或试验亚组中的患者在同一疾病发作期间未达到先前使用标准抗抑郁药的缓解来进行亚组分析。6 周后，我们得到了以下效应量：总体效应量：Hedges' = -0.67，95%CI = 0.03。有记录的未缓解亚组：Hedges' = -0.97，95%CI = 0.001。无记录的未缓解组-0.35，95%CI = 0.24。12 周后：总体效应量：Hedges' = -1.0，95%CI = 0.03。有记录的未缓解亚组：Hedges' = -1.46，95%CI < 0.001。无记录的未缓解组：Hedges' = -0.54，95%CI = 0.07。
我们提供了锌与安慰剂作为抗抑郁药辅助治疗的疗效初步证据。
