单细胞方法在研究骨髓增殖性肿瘤生物学中的应用。
Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology.
机构信息
Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine and NIHR Biomedical Research Centre, University of Oxford, Headley Way, Oxford OX39DS, UK.
Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Biomedical Research Centre, University of Oxford, Headley Way, Oxford OX3 9DS, UK.
出版信息
Hematol Oncol Clin North Am. 2021 Apr;35(2):279-293. doi: 10.1016/j.hoc.2021.01.002.
Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.
费城阴性骨髓增殖性肿瘤（MPN）是人类癌症生物学多个方面的优秀可处理疾病模型，包括遗传进化、组织相关纤维化和癌症干细胞。在这篇综述中，我们讨论了从应用多种新的单细胞技术研究人类疾病中获得的关于 MPN 生物学的最新见解，特别关注单细胞基因组学、单细胞转录组学和数字病理学。
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