Kaliyamoorthy Kiruthiga, Pillai Archana Sumohan, Alexander Aleyamma, Arivarasu Anitha, Enoch Israel V M V, Ramasamy Sivaraj
Department of Chemistry, Hindustan Institute of Technology & Science (Deemed-to-be University), Kelambakkam, Chennai 603103, Tamil Nadu, India.
Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences (Deemed-to-be University), Coimbatore 641114, Tamil Nadu, India.
Mater Sci Eng C Mater Biol Appl. 2021 Mar;122:111796. doi: 10.1016/j.msec.2020.111796. Epub 2020 Dec 16.
Biocompatible polymer-coated magnetic nanoparticles are designed with an objective to sharp-shoot cancer by loading anticancer drugs on them and delivering to the target site. In this work, novel biocompatible polymers of poly(dl-lactic-co-glycolide), functionalized with β-cyclodextrin and β-cyclodextrin-folate conjugate are synthesized and characterized by spectroscopic techniques. Magnetic ytterbium ferrite nanoparticles are prepared, and the synthesized polymers are coated on them. The polymer-coated nanoparticles are intended to be employed as magnetic nanocarriers that transport the anticancer drug, camptothecin. The ferrite nanoparticles are superparamagnetic in nature. Camptothecin was loaded in the nanocarriers and the adsorption percentage was near or above 90%. Study of the in vitro release of camptothecin from the nanocarrier reveals its sustained nature, i.e. a cumulative release of about 50% at 72 h and a pH of 7.4. A pH-dependent enhanced release of 60% is observed, i.e. at a more acidic pH of 6.8. In vitro anti-cancer studies on breast cancer cell lines (MCF7) were carried out. The cell inhibition is enhanced in the case of camptothecin-loaded nanocarrier. The enhanced efficacy of the camptothecin, its sustained release, and the size of the nanocarrier in the range that is considered suitable for magnetic field-assisted drug delivery reveal the magnetic nanocarrier promising for transport of the drug.
设计具有生物相容性的聚合物包覆磁性纳米颗粒，目的是通过在其上负载抗癌药物并将其递送至靶位点来精准治疗癌症。在这项工作中，合成了用β-环糊精和β-环糊精-叶酸共轭物功能化的新型聚（dl-乳酸-共-乙醇酸）生物相容性聚合物，并通过光谱技术对其进行了表征。制备了磁性镱铁氧体纳米颗粒，并将合成的聚合物包覆在其上。聚合物包覆的纳米颗粒旨在用作运输抗癌药物喜树碱的磁性纳米载体。铁氧体纳米颗粒本质上是超顺磁性的。喜树碱被负载到纳米载体中，吸附率接近或高于90%。对喜树碱从纳米载体的体外释放研究表明其具有缓释特性，即在72小时和pH值为7.4时累积释放约50%。在更酸性的pH值6.8时，观察到pH依赖性增强释放，释放率为60%。对乳腺癌细胞系（MCF7）进行了体外抗癌研究。在负载喜树碱的纳米载体的情况下，细胞抑制作用增强。喜树碱的增强疗效、其缓释以及纳米载体的尺寸在适合磁场辅助药物递送的范围内，表明磁性纳米载体在药物运输方面具有潜力。
