Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed University), Coimbatore 641114, Tamil Nadu, India.
Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram 608002, Tamil Nadu, India.
Curr Drug Deliv. 2024;21(8):1128-1141. doi: 10.2174/1567201821666230817122011.
Among various materials designed for anticancer drug transport, sulfide nanoparticles are uniquely intriguing owing to their spectral characteristics. Exploration of newer nanoscale copper sulfide particles with dysprosium doping is reported herein. It leads to a change in the physicochemical properties of the sulfide nanoparticles and hence the difference in drug release and cytotoxicity.
We intend to purport the suitably engineered cobalt sulfide and dysprosium-doped cobalt sulfide nanoparticles that are magnetic and NIR-absorbing, as drug delivery vehicles. The drug loading and release are based on the supramolecular drug complex formation on the surface of the nanoparticles.
The nanomaterials are synthesized employing hydrothermal procedures, coated with a biocompatible poly-β-cyclodextrin, and characterized using the methods of diffractometry, microscopy, spectroscopy, thermogravimetry and magnetometry. The sustained drug release is investigated . 5-Fluorouracil is loaded in the nanocarriers. The empty and 5-fluorouracil-loaded nanocarriers are screened for their anti-breast cancer activity on MCF-7 cells.
The size of the nanoparticles is below 10 nm. They show soft ferromagnetic characteristics. Further, they show broad NIR absorption bands extending up to 1200 nm, with the dysprosium-doped material displaying greater absorbance. The drug 5-fluorouracil is encapsulated in the nanocarriers and released sustainably, with the expulsion duration extending over 10 days. The IC of the blank and the drug-loaded cobalt sulfide are 16.24 ± 3.6 and 12.2 ± 2.6 μg mL, respectively. For the drug-loaded, dysprosium-doped nanocarrier, the IC value is 9.7 ± 0.3 μg mL.
The ultrasmall nanoparticles possess a size suitable for drug delivery and are dispersed well in the aqueous medium. The release of the loaded 5-fluorouracil is slow and sustained. The anticancer activity of the drug-loaded nanocarrier shows an increase in efficacy, and the cytotoxicity is appreciable due to the controlled release. The nanocarriers show multi-functional characteristics, , magnetic and NIR-absorbing, and are promising drug delivery agents.
在设计用于抗癌药物输送的各种材料中，硫化物纳米粒子因其光谱特性而格外引人注目。本文报道了对具有掺杂 dysprosium 的新型纳米级铜硫化物粒子的探索。这导致了硫化物纳米粒子的物理化学性质的变化，从而导致了药物释放和细胞毒性的差异。
我们旨在提供合适设计的具有磁性和近红外吸收的钴硫化物和掺杂 dysprosium 的钴硫化物纳米粒子作为药物输送载体。药物负载和释放基于纳米粒子表面上的超分子药物络合物的形成。
纳米材料通过水热程序合成，用生物相容性的聚-β-环糊精包覆，并通过衍射、显微镜、光谱、热重法和磁强计等方法进行表征。研究了持续的药物释放。5-氟尿嘧啶被加载到纳米载体中。筛选空纳米载体和载有 5-氟尿嘧啶的纳米载体对 MCF-7 细胞的抗乳腺癌活性。
纳米粒子的尺寸小于 10nm。它们显示软铁磁特性。此外，它们显示出宽的近红外吸收带，延伸至 1200nm，掺杂 dysprosium 的材料显示出更大的吸收度。药物 5-氟尿嘧啶被包裹在纳米载体中并持续释放，排出持续时间超过 10 天。空白和载药钴硫化物的 IC 分别为 16.24±3.6 和 12.2±2.6μg/mL。对于载药掺杂 dysprosium 的纳米载体，IC 值为 9.7±0.3μg/mL。
超小纳米粒子具有适合药物输送的尺寸，并在水性介质中分散良好。负载的 5-氟尿嘧啶的释放缓慢且持续。载药纳米载体的抗癌活性显示出功效的提高，由于控制释放，细胞毒性是明显的。纳米载体具有多能特性，磁性和近红外吸收，是有前途的药物输送剂。
